Journal ArticleDOI
Serotonergic dorsal raphe neurons cease firing by disfacilitation during paradoxical sleep
Kazuya Sakai,Sylvain Crochet +1 more
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TLDR
The present data suggest that this cessation of dorsal raphe unit activity is caused by the mechanism of disfacilitation resulting from the cessation of discharge of norepinephrine- or histamine-containing neurons during PS.Abstract:
Using in vivo extracellular unit recordings combined with microdialysis infusion in the cat, we found that the cessation of discharge of presumed serotonergic dorsal raphe neurons during paradoxical sleep (PS) was completely blocked by either histamine or phenylephrine, an alpha1 adrenoceptor agonist, but not by bicuculline, a GABA receptor antagonist. In addition, application of mepyramine, a specific H1 histamine receptor antagonist, or prazosin, a specific alpha1 adrenoceptor antagonist, suppressed the spontaneous discharge of raphe neurons during both quiet waking and sleep. The present data suggest that this cessation of dorsal raphe unit activity is caused by the mechanism of disfacilitation resulting from the cessation of discharge of norepinephrine- or histamine-containing neurons during PS.read more
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References
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Book
Brainstem control of wakefulness and sleep
TL;DR: A monograph communicating the current realities and future possibilities of unifying basic studies on anatomy and cellular physiology with investigations of the behavioral and physiological events of waking and sleep.
Journal ArticleDOI
Dorsal raphe neurons: depression of firing during sleep in cats.
Dennis McGinty,Ronald M. Harper +1 more
TL;DR: The results of lesion and pharmacological experiments suggest that 5-HT-containing neurons localized in the raphe nuclei of the brain stem participate functionally in the control of slow wave sleep (SWS) 24-27 as well as in a variety of waking behavioral processes s,l°.
Journal ArticleDOI
Raphe unit activity in freely moving cats: Correlation with level of behavioral arousal
TL;DR: The hypothesis that serotonin may play a modulatory, rather than mediative, role in behavioral and physiological processes is discussed in relation to the hypothesis that neurotransmitter levels in the brain are modulatory and not mediative.
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