Journal ArticleDOI
Serotonin (5-HT) release in the dorsal raphé and ventral hippocampus: raphé control of somatodendritic and terminal 5-HT release.
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TLDR
Evidence is provided that 5-HT release in the dorsal raphé is dependent on the opening of fast activated sodium channels and that dorsal rapho-HT1a receptors control somatodendritic and hippocampal 5- HT release.Abstract:
Somatodendritic and terminal release of serotonin (5-HT) was investigated by simultaneously measuring extracellular concentrations of 5-HT, 5-hydroxyindole-3-acetic acid (5-HIAA) and homovanillic acid (HVA) in the dorsal raphe and ventral hippocampus in freely moving rats. Perfusion of tetrodotoxin (TTX, 1μM and 10μM) into the dorsal raphe simultaneously decreased dorsal raphe and hippocampal 5-HT release. However, following TTX perfusion into the hippocampus (10μM), hippocampal 5-HT release was profoundly reduced but dorsal raphe 5-HT remained unchanged.read more
Citations
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Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor.
Steven F. Maier,Linda R. Watkins +1 more
TL;DR: The nature of learned helplessness, as well as the role of the dorsal raphe nucleus, serotonin, and corticotropin-releasing hormone in mediating the behavioral effects of uncontrollable stressors, are discussed.
Journal ArticleDOI
Brain microdialysis of GABA and glutamate : What does it signify?
W Timmerman,Ben H.C. Westerink +1 more
TL;DR: It is concluded that synaptic transmission of GABA and glutamate is strictly compartmentalized and as a result, these amino acids can hardly leak out of the synaptic cleft and reach the extracellular space where the dialysis probe samples.
Journal ArticleDOI
Serotonin, stress and corticoids.
TL;DR: The data presented reinforce the hypothesis that stress affects serotonergic transmission responses to aversive stimuli, partly through the actions of corticoids, and the need to consider the environment and genetic status when assessing the effects of stress on 5-HT neurotransmission is underlined.
Journal ArticleDOI
Origin and functional role of the extracellular serotonin in the midbrain raphe nuclei.
TL;DR: Overall, it appears that the extracellular concentration of 5-HT in the DR and the MnR is tightly controlled by intrinsic serotonergic mechanisms as well as afferent connections.
Journal ArticleDOI
5-Hydroxytryptamine 2C Receptors in the Basolateral Amygdala Are Involved in the Expression of Anxiety After Uncontrollable Traumatic Stress
John P. Christianson,Thomas Ragole,Jose Amat,Benjamin N. Greenwood,Paul V. Strong,Evan D. Paul,Monika Fleshner,Linda R. Watkins,Steven F. Maier +8 more
TL;DR: The results suggest that the anxiety-like behavior observed after uncontrollable stress is mediated by exaggerated 5-HT acting at BLA 5- HT(2C) receptors.
References
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Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat
Efrain C. Azmitia,Menahem Segal +1 more
TL;DR: The differential projections from the dorsal raphe and median raphe nuclei of the midbrain were autoradiographically traced in the rat brain after 3H‐proline micro‐injections to identify six ascending fiber tracts.
Journal ArticleDOI
Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists.
TL;DR: D dorsal raphe 5‐HT neurons appear highly responsive to 5‐ht1A, but not to 5-HT1B compounds; these findings are discussed with regard to the 5‐ HT receptor subtypes as candidates for the somatodendritic autoreceptor of dorsal raphes neurons.
Journal ArticleDOI
Functional Correlates of Serotonin 5-HT1 Recognition Sites
TL;DR: It is shown that functional correlates do indeed exist for subtypes of 5-HT1 recognition sites; moreover, these are markedly different from the effects mediated by 5- HT2 (5-HT D) or 5 -HT3 (5 -HT M) receptors.
Journal ArticleDOI
Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: electrophysiological studies in the rat brain.
Pierre Blier,Claude de Montigny +1 more
TL;DR: It is concluded that the progressive restoration of the firing activity of 5‐HT neurons, due to a desensitization of the somatodendritic 5‐ HT autoreceptor, combined with the direct activation of normosensitive postsynaptic5‐HT1A receptor by gepirone, should result in an augmented tonic activation of post Synaptic 5‐ht1A receptors.