Short-term effects of repetitive transcranial magnetic stimulation on speech and voice in individuals with Parkinson's disease.
TLDR
Results showed that there were no significant differences between any of the conditions regarding duration of sustained fricative or sustained vowel phonation, diadochokinetic rates or intelligibility, but there was a significant reduction in fundamental frequency variation, pitch period perturbation, noise-to-harmonics ratio and coefficient of variation in F₀ between the recordings performed before compared to after sham stimulation.Abstract:
The main characteristics of dysarthria in Parkinson's disease (PD) are monotony of pitch and loudness, reduced stress, variable speech rate, imprecise consonants, and breathy and harsh voice. Earlier treatment studies have shown that dysarthria is less responsive to both pharmacological and surgical treatments than other gross motor symptoms. Recent findings have suggested that repetitive transcranial magnetic stimulation (rTMS) may have a beneficial effect on vocal function in PD. In the present study, 10 individuals with mild PD and no or minimal dysarthria were treated with rTMS as well as placebo stimulation in a blinded experiment. Stimulation was delivered using a frequency of 10 Hz and a stimulation intensity of 90% of the motor threshold. The site of stimulation was the cortical area corresponding to the hand, on the hemisphere contralateral to the patient's most affected side. The participants were audio-recorded before and after both rTMS and sham stimulation. Acoustic analysis was performed on 3 sustained /a:/ for each of the 4 conditions, and analyzed both for the whole group as well as for men and women separately. Results showed that there were no significant differences between any of the conditions regarding duration of sustained fricative or sustained vowel phonation, diadochokinetic rates or intelligibility. Above all, the results of acoustic analyses showed an effect of placebo; there was a significant reduction in fundamental frequency (F(0)) variation, pitch period perturbation, amplitude period perturbation, noise-to-harmonics ratio and coefficient of variation in F(0) between the recordings performed before compared to after sham stimulation.read more
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Journal ArticleDOI
Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS)
Jean Pascal Lefaucheur,Nathalie André-Obadia,Andrea Antal,Samar S. Ayache,Chris Baeken,David H. Benninger,Roberto Cantello,Massimo Cincotta,Mamede de Carvalho,Dirk De Ridder,Hervé Devanne,Vincenzo Di Lazzaro,Saša R. Filipović,Friedhelm C. Hummel,Satu K. Jääskeläinen,Vasilios K. Kimiskidis,Giacomo Koch,Berthold Langguth,Thomas Nyffeler,A. Oliviero,Frank Padberg,Emmanuel Poulet,Simone Rossi,Paolo Maria Rossini,John C. Rothwell,Carlos Schönfeldt-Lecuona,Hartwig R. Siebner,Christina W. Slotema,Charlotte J. Stagg,Josep Valls-Solé,Ulf Ziemann,Walter Paulus,Luis Garcia-Larrea +32 more
TL;DR: There is a sufficient body of evidence to accept with level A (definite efficacy) the analgesic effect of high-frequency rTMS of the primary motor cortex (M1) contralateral to the pain and the antidepressant effect of HF-rT MS of the left dorsolateral prefrontal cortex (DLPFC).
Journal ArticleDOI
Speech disorders in Parkinson's disease: early diagnostics and effects of medication and brain stimulation.
TL;DR: 14 combinations of speech tasks and acoustic features that can be recommended for use in describing the main features of HD in PD seem to be mainly related to non-dopaminergic deficits and associated particularly with non-motor symptoms.
Journal ArticleDOI
Therapeutic applications of repetitive transcranial magnetic stimulation (rTMS) in movement disorders: a review.
TL;DR: The current knowledge on the therapeutic applications of rTMS in various movement disorders is discussed, notably Parkinson's disease, dystonia, Tourette's syndrome etc.
Journal ArticleDOI
Acoustic evaluation of short-term effects of repetitive transcranial magnetic stimulation on motor aspects of speech in Parkinson’s disease
Ilona Eliasova,Jiri Mekyska,Milena Kostalova,Milena Kostalova,Radek Mareček,Zdenek Smekal,Irena Rektorová +6 more
TL;DR: The pilot results indicate that one session of rTMS applied over the SM1 may lead to measurable improvement in voice quality and intensity and an increase in speech rate and tongue movements and the positive results of acoustic analysis were not reflected in a subjective rating of speech performance quality as assessed by a speech therapist.
Journal ArticleDOI
Safety of transcranial magnetic stimulation in Parkinson's disease: A review of the literature
TL;DR: It is concluded that current TMS and rTMS protocols do not pose significant risks to PD patients and would recommend that TMS users in this population follow the most recent safety guidelines but do not warrant additional precautions.
References
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Journal ArticleDOI
Non-invasive magnetic stimulation of human motor cortex
Journal ArticleDOI
Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease
TL;DR: High-frequency deep brain stimulation of the subthalamic nucleus is a powerful method that is currently unchallenged in the management of Parkinson's disease, but its long-term effects must be thoroughly assessed.
Book ChapterDOI
Deep Brain Stimulation of the Subthalamic Nucleus for the Treatment of Parkinson's Disease
TL;DR: A comprehensive review of the current literature on the topic is presented in addition to the authors' own results with STN DBS for the treatment of PD, finding good pre-operative levodopa responsiveness and younger age appear to be the best predictors of surgical success, particularly with respect to improvement in motor function.
Journal ArticleDOI
Progression of Dysarthria and Dysphagia in Postmortem-Confirmed Parkinsonian Disorders
Jörg Müller,Gregor K. Wenning,Marc Verny,Ann C. McKee,K. Ray Chaudhuri,Kurt A. Jellinger,Werner Poewe,Irene Litvan +7 more
TL;DR: Evaluated and adequate treatment of patients with PD who complain of dysphagia might prevent or delay complications such as aspiration pneumonia, which in turn may improve quality of life and increase survival time.
Book
Clinical management of sensorimotor speech disorders
TL;DR: This volume is organized by syndrome, and is divided into the following three sections: nature and differential diagnosis; clinical assessment; clinical management, with a major emphasis on specific treatment techniques.
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