Journal ArticleDOI
Signaling Recognition Events with Fluorescent Sensors and Switches
A.P. de Silva,H. Q. N. Gunaratne,Thorfinnur Gunnlaugsson,Allen J. M. Huxley,Colin P. McCoy,Jude T. Rademacher,Terence E. Rice +6 more
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This article is published in ChemInform.The article was published on 1997-10-28. It has received 235 citations till now.read more
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Reaction-based small-molecule fluorescent probes for chemoselective bioimaging
TL;DR: A survey of tools and tactics for using small-molecule fluorescent probes to detect biologically important chemical analytes is presented, highlighting design criteria for effective chemical tools for use in biological applications as well as gaps for future exploration.
Journal ArticleDOI
Selective molecular imaging of viable cancer cells with pH-activatable fluorescence probes.
Yasuteru Urano,Daisuke Asanuma,Yukihiro Hama,Yukihiro Hama,Yoshinori Koyama,Yoshinori Koyama,Tristan Barrett,Tristan Barrett,Mako Kamiya,Tetsuo Nagano,Toshiaki Watanabe,Akira Hasegawa,Peter L. Choyke,Hisataka Kobayashi +13 more
TL;DR: A newly designed targeted 'activatable' fluorescent imaging probe that is highly specific for tumors with minimal background signal and can be widely adapted to cancer-specific, cell surface–targeting molecules that result in cellular internalization.
Journal ArticleDOI
Small-molecule fluorescent sensors for investigating zinc metalloneurochemistry.
TL;DR: This Account summarizes work by the laboratory addressing the design, preparation, characterization, and use of small-molecule fluorescent sensors for imaging Zn(II) in living cells and samples of brain tissue, and devised sensors with varied photophysical and metal-binding properties.
Journal ArticleDOI
Fluoride ion recognition by chelating and cationic boranes.
TL;DR: This work demonstrates that Coulombic and chelate effects are additive and can be combined to boost the anion affinity of Lewis acidic hosts and to overcome the incompatibility of these systems with aqueous media.
Journal ArticleDOI
Fluorescent probes for bioimaging applications.
Takuya Terai,Tetsuo Nagano +1 more
TL;DR: This review recounts some recent achievements in the field of small-molecular fluorescent probes, and methodologies to visualize proteases are discussed, with special emphasis on activity-based probes for use in vivo.
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