Journal ArticleDOI
Skeletal myogenesis in the mouse esophagus does not occur through transdifferentiation.
TLDR
Examination of embryonic and postnatal tissues revealed that esophageal skeletal muscle does not arise from transdifferentiation of committed smooth muscle cells.Abstract:
Summary: To determine the developmental history of murine esophageal skeletal muscle, smooth muscle cells were fate mapped by lineage-specific recombination and phenotypically marked by eGFP. Examination of embryonic and postnatal tissues revealed that esophageal skeletal muscle does not arise from transdifferentiation of committed smooth muscle cells. genesis 36:81–82, 2003. © 2003 Wiley-Liss, Inc.read more
Citations
More filters
Journal ArticleDOI
Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster
Thomas Boettger,Nadine Beetz,Sawa Kostin,Johanna Schneider,Marcus Krüger,Lutz Hein,Thomas Braun +6 more
TL;DR: It is demonstrated that the mouse miR-143/145 cluster, expression of which is confined to SMCs during development, is required for VSMC acquisition of the contractile phenotype and manipulated expression may offer a new approach for influencing vascular repair and attenuating arteriosclerosis pathogenesis.
Journal ArticleDOI
Foxp2 and Foxp1 cooperatively regulate lung and esophagus development.
TL;DR: These data identify Foxp2 and Foxp1 as crucial regulators of lung and esophageal development, underscoring the necessity of these transcription factors in the development of anterior foregut-derived tissues and demonstrating functional cooperativity between members of the Foxp 1/2/4 family in tissues where they are co-expressed.
Journal ArticleDOI
SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation
Xingbin Ai,Toshio Kitazawa,Anh Tri Do,Marion Kusche-Gullberg,Patricia A. Labosky,Charles P. Emerson +5 more
TL;DR: Findings provide the first in vivo evidence that Sulfs are essential developmental regulators of cellular HS 6-O-sulfation for matrix transmission and reception of GDNF signal from muscle to innervating neurons.
Journal ArticleDOI
Conversion of columnar to stratified squamous epithelium in the developing mouse oesophagus
TL;DR: An in vitro model based on oesophageal explants isolated from E11.5d mouse embryos, which fully recapitulates the normal in vivo development, shows that the squamous epithelium arises from the columnar epithelial layer by a direct conversion process.
Journal ArticleDOI
Transdifferentiation, Metaplasia and Tissue Regeneration
TL;DR: A review examines in detail some well-documented examples of transdifferentiation, speculates on the potential molecular and cellular mechanisms that underlie the switches in phenotype, together with their significance to organogenesis and regenerative medicine.
References
More filters
Journal ArticleDOI
How cells change their phenotype
David Tosh,Jonathan M.W. Slack +1 more
TL;DR: This review examines recently discovered cases of metaplasia, and speculates on the potential molecular and cellular mechanisms that underlie the switches, and their significance to developmental biology and medicine.
Journal ArticleDOI
Evidence for Developmentally Programmed Transdifferentiation in Mouse Esophageal Muscle
TL;DR: The musculature of the mouse esophagus was found to undergo a conversion from smooth muscle in the fetus to skeletal muscle during early postnatal development, which suggests that this conversion is a result of programmed transdifferentiation.
Journal ArticleDOI
Smooth muscle expression of Cre recombinase and eGFP in transgenic mice.
TL;DR: The generation of transgenic mice designed to facilitate the study of vascular and nonvascular smooth muscle biology in vivo are reported, using a bicistronic transgene consisting of Cre recombinase and enhanced green fluorescent protein (eGFP) coding sequences.
Journal ArticleDOI
Both smooth and skeletal muscle precursors are present in foetal mouse oesophagus and they follow different differentiation pathways.
Wanfeng Zhao,Gurtej K. Dhoot +1 more
TL;DR: It is concluded that the transient appearance of smooth muscle cells may provide a scaffold for the laying down of skeletal muscle layers in mouse oesophagus, the final disappearance of which may be triggered by lack of smoother muscle innervation.
Related Papers (5)
Evidence for Developmentally Programmed Transdifferentiation in Mouse Esophageal Muscle
Transdifferentiation of esophageal smooth to skeletal muscle is myogenic bHLH factor-dependent
Both smooth and skeletal muscle precursors are present in foetal mouse oesophagus and they follow different differentiation pathways.
Wanfeng Zhao,Gurtej K. Dhoot +1 more