Journal ArticleDOI
Small RNA chaperones for ribosome biogenesis.
TLDR
What is known about how a set of small nuclear RNAs participate in the conversion of the long precursor RNAs to the mature 18S, 5.8S, and 28S rRNAs of the ribosome is discussed.Abstract:
The Howard Hughes Medical Institute, Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06536-0812, USA. A set of small nuclear RNAs of 50 to 200 nucleotides resides in the nucleolus of the cell, the region of the nucleus in which ribosomes are made. J. A. Steitz and K. T. Tycowski discuss what is known about how these RNAs participate in the conversion of the long precursor RNAs to the mature 18 S , 5.8 S , and 28 S rRNAs of the ribosome.read more
Citations
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The noncoding RNA revolution-trashing old rules to forge new ones.
TL;DR: The pathway of ncRNA research is described, where every established "rule" seems destined to be overturned.
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Unconventional Methods for Fabricating and Patterning Nanostructures.
TL;DR: Lithography with Neutral Metastable Atoms 1838 4.1.
Journal ArticleDOI
Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs.
Zsuzsanna Kiss-László,Yves Henry,Jean-Pierre Bachellerie,Michèle Caizergues-Ferrer,Tamás Kiss +4 more
TL;DR: The conclusion that sno-RNAs function in covalent modification of the sugar moieties of ribonucleotides demonstrates that eukaryotic small nuclear RNAs have a more versatile cellular function than earlier anticipated.
Journal ArticleDOI
Targeted ribose methylation of RNA in vivo directed by tailored antisense RNA guides
TL;DR: It is shown that altering the sequence of the snoRNA is sufficient to change the specificity of methylation and endogenous non-ribosomal RNA can thus be targeted, possibly providing a highly selective tool for the alteration of gene expression at the post-transcriptional level.
Journal ArticleDOI
The snoRNA MBII-52 (SNORD 115) is processed into smaller RNAs and regulates alternative splicing
Shivendra Kishore,Amit Khanna,Zhaiyi Zhang,Jingyi Hui,Piotr J. Balwierz,Mihaela Stefan,C.M. Beach,Robert D. Nicholls,Mihaela Zavolan,Stefan Stamm,Stefan Stamm +10 more
TL;DR: Data indicate that not a traditional C/D box snoRNA MBII-52, but a processed version lacking the sno RNA stem is the predominant MBIi-52 RNA missing in PWS, and its substitution could be a therapeutic principle for PWS.
References
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Journal ArticleDOI
Visualization of Nucleolar Genes
O. L. Miller,Barbara R. Beatty +1 more
TL;DR: The presence of extrachromosomal nucleoli in amphibian oocytes has permitted isolation and electron microscopic observation of the genes coding for ribosomal RNA precursor molecules.
Journal ArticleDOI
The Small Nucleolar RNAs
E S Maxwell,M J Fournier +1 more
TL;DR: The present review summarizes key progress made in characterizing the small nucleolar RNAs (snoRNAs) of eukaryotic cells.
Journal ArticleDOI
Depletion of U3 small nucleolar RNA inhibits cleavage in the 5' external transcribed spacer of yeast pre-ribosomal RNA and impairs formation of 18S ribosomal RNA
J. M. X. Hughes,Manuel Ares +1 more
TL;DR: The similarity between the effects of U3 depletion and depletion of U14 small nucleolar RNA and the nucleolar protein fibrillarin (NOP1) suggests that these could be components of a single highly conserved processing complex.
Journal ArticleDOI
Depletion of U14 small nuclear RNA (snR128) disrupts production of 18S rRNA in Saccharomyces cerevisiae.
TL;DR: Repression of an essential nucleolar small nuclear RNA (snRNA) gene of Saccharomyces cerevisiae was shown to result in impaired production of 18S rRNA, and a common U14 designation is proposed for the structurally related yeast snRNA and 4.5S hybRNAs from amphibians and mammals.
Journal ArticleDOI
Disruption of U8 nucleolar snRNA inhibits 5.8S and 28S rRNA processing in the Xenopus oocyte.
Brenda A. Peculis,Joan A. Steitz +1 more
TL;DR: Results indicate that the U8 snRNP is essential for correct maturation of the 5.8S and 28S rRNAs at both their 5' and 3' ends, and U8 is therefore a nucleolar snRNA implicated in a nucleolytic rRNA processing step other than 18S maturation.