Journal ArticleDOI
Sodium Salts (NaI/NaBr/NaCl) for the Halogenation of Imidazo-Fused Heterocycles.
TLDR
An effective method for the halogenation of imidazo-fused heterocycles using readily available sodium salts (NaCl/NaBr/NaI) as halogen source and K2S2O8 (or) oxone as promoter is reported.Abstract:
We report herein an effective method for the halogenation of imidazo-fused heterocycles using readily available sodium salts (NaCl/NaBr/NaI) as halogen source and K2S2O8 (or) oxone as promoter. A variety of C-3 halogenated imidazo[1,2- a]pyridines and benzo[d]imidazo[2,1- b]thiazoles were obtained in good to excellent yields. The present method of halogenation has been also extended to 2-aminopyridines, 2-aminopyrimidine, indole, and isoquinoline with moderate to excellent yields.read more
Citations
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Journal ArticleDOI
C3‐Functionalization of Imidazo[1,2‐a]pyridines
Journal ArticleDOI
Trihaloisocyanuric acids in ethanol: an eco-friendly system for the regioselective halogenation of imidazo-heteroarenes
José S. S. Neto,Renata A. Balaguez,Marcelo S. Franco,Victor C. de Sá Machado,Sumbal Saba,Jamal Rafique,Fábio Z. Galetto,Antonio L. Braga +7 more
TL;DR: An efficient, rapid and benign protocol for the direct C(sp2)–H bond halogenation of 2-arylimidazo[1,2-a]pyridines using trihaloisocyanuric acids in ethanol was successfully extended to imidazopyrimidine,Imidazothiazole and indazole heterocycles showing the broadness of this useful approach.
Journal ArticleDOI
Visible-light induced phosphonation of quinoxalines and quinoxalin-2(1H)-ones under aerobic metal-free conditions
TL;DR: In this paper, the authors described the phosphonation of quinoxalines using aerobic oxygen as green oxidant under visible light conditions at room temperature, and the control experiments revealed the present transformation proceeds through a radical mechanism.
Journal ArticleDOI
Recent advances in radical C-H bond functionalization of imidazoheterocycles
Om P. S. Patel,Om P. S. Patel,Nitesh Kumar Nandwana,Nitesh Kumar Nandwana,Lesetja J. Legoabe,Bhaskar C. Das,Anil Kumar +6 more
Journal ArticleDOI
Enhancing intradermal delivery of tofacitinib citrate: Comparison between powder-loaded hollow microneedle arrays and dissolving microneedle arrays.
Álvaro Cárcamo-Martínez,Brónach Mallon,Qonita Kurnia Anjani,Juan Domínguez-Robles,Emilia Utomo,Lalitkumar K. Vora,Ismael A. Tekko,Eneko Larrañeta,Ryan F. Donnelly +8 more
TL;DR: The aim of this research was to enhance the intradermal delivery of tofacitinib citrate with MN arrays and their potential for treatment of autoimmune skin diseases.
References
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Journal ArticleDOI
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TL;DR: In this paper, the Negishi Coupling and its recent advances Carbon-Carbon Bond Forming Reactions Mediated by Organozinc Reagents and Organomagnesium Reagents in Cross-Coupling Reactions.
Journal ArticleDOI
Derivatives of Imidazole. I. Synthesis and Reactions of Imidazo[1,2-α]pyridines with Analgesic, Antiinflammatory, Antipyretic, and Anticonvulsant Activity
Luigi Almirante,Luigi Polo,Alfonso Mugnaini,Ercolina Provinciali,Pierluigi Rugarli,Adriana Biancotti,Afro Gamba,Walter Murmann +7 more