Journal ArticleDOI
Sol-gel coatings for optical chemical sensors and biosensors
Brian D. MacCraith,Colette McDonagh,Gerard O'Keeffe,Aisling K. McEvoy,T. Butler,Fidelma R. Sheridan +5 more
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TLDR
In this article, an overview of the state-of-the-art of optical sensors employing sol-gel-derived coatings is presented, which is particularly suited to the side-coating of optical fibres or waveguides in evanescent-wave sensors.Abstract:
In this paper an overview is presented of the state-of-the-art of optical sensors employing sol-gel-derived coatings. The technique is particularly suited to the side-coating of optical fibres or waveguides in evanescent-wave sensors because precise control of sensitivity-determining parameters, such as the coating thickness and length, is achievable. Sensors based on entrapped organic and inorganic dyes, enzymes and other biomolecules have been reported. The main features of the process are illustrated by examples of chemical sensors and biosensors from the literature. In particular, the development of an oxygen sensor based on the quenching of fluorescence from a sol-gel-entrapped ruthenium complex and an absorption-based pH sensor are described. Issues that require further investigation before this technology can proceed to the stage of industrial development are also highlighted.read more
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Journal ArticleDOI
Design of fluorescent materials for chemical sensing
TL;DR: This critical review shows the use of polymers, sol-gels, mesoporous materials, surfactant aggregates, quantum dots, and glass or gold surfaces, combined with different chemical approaches for the development of fluorescent sensing materials.
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Encapsulation of Biologicals within Silicate, Siloxane, and Hybrid Sol−Gel Polymers: An Efficient and Generic Approach
TL;DR: In this article, a new class of precursors, based around polyol silicates, derived from glycerol, was described and employed for sol−gel bioentrapment in an approach distinguished by a high biocompatibility and mild encapsulation conditions, and which enables the reproducible and efficient confinement of proteins and cells inside silica.
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Entrapment of biomolecules in sol-gel matrix for applications in biosensors: problems and future prospects.
R. Gupta,Nabo Kumar Chaudhury +1 more
TL;DR: This review focuses on the growing field of entrapment of biomolecules such as proteins, enzymes and antibodies in sol-gel matrices prepared from alkoxide precursors.
Journal ArticleDOI
Biosensors: recent advances
A F Collings,Frank Caruso +1 more
TL;DR: In this paper, the authors discuss recent advances in biosensor technology which draw on the disciplines of physics, chemistry, biochemistry and electronics, and comment briefly on practical factors affecting the commercialization of various biosensors.
Journal ArticleDOI
Optical sensors and biosensors based on sol-gel films.
TL;DR: An overview of the state-of-the-art of sol-gel thin films-based optical sensors is presented and applications reviewed include sensors for determination of pH, gases, ionic species and solvents, as well as biosensors.
References
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Sol-gel science
TL;DR: In this article, the authors present and understand the sol-gel processing sequence from beginning to end, including discussions on the chemistry of hydrolysis and condensation of metal-organics and inorganic salts, the growth of polymeric or particulate species in sols, gelation, aging of gels, drying, structure of Gels, and sintering.
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Encapsulation of proteins in transparent porous silicate glasses prepared by the sol-gel method
Lisa M. Ellerby,Clinton R. Nishida,Fumito Nishida,Stacey A. Yamanaka,Bruce Dunn,Joan Selverstone Valentine,Jeffrey I. Zink +6 more
TL;DR: Novel sol-gel synthetic techniques were used to immobilize copper-zinc superoxide dismutase, cytochrome c, and myoglobin by encapsulation in stable, optically transparent, porous silica glass matrices under mild conditions such that the biomolecules retained their characteristic reactivities and spectroscopic properties.
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Biochemically active sol-gel glasses: The trapping of enzymes ☆
TL;DR: The immobilized purified ALP from bovine intestinal mucosa had a 30% activity yield and an improved stability to thermal deactivation compared to a solution, and the composite bioactive glass was preserved in water at room temperature for two months without loosing activity.
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Doped sol-gel glasses as chemical sensors
TL;DR: In this paper, it is reported that by trapping suitable analytical reagents, porous sol-gel glasses can be used for the preparation of a wide variety of chemical-sensing materials, based on the observation that a substantial fraction of the trapped molecules is exposed to the liquid or gaseous intra-pore volume.