Journal ArticleDOI
Species differences in adrenal spironolactone metabolism: relationship to cytochrome P-450 destruction
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This article is published in Biochemical Pharmacology.The article was published on 1988-01-15. It has received 5 citations till now. The article focuses on the topics: Cytochrome & Cytochrome P450.read more
Citations
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Journal ArticleDOI
Spironolactone in dermatologic therapy
TL;DR: The use of spironolactone as an antiandrogen in dermatologic therapy is reviewed, the endocrinologic effects, pharmacology, dermatologic uses, and side effects are discussed, and guidelines for its use are provided.
Journal ArticleDOI
Substrate specificities and functions of the p450 cytochromes
TL;DR: Current focus is on the identification and acquisition of sequence information on hereto unidentified and/or uncharacterized P450 isoforms and ascertainment of the specific functions of specific, individual isoforms.
Journal ArticleDOI
Mineralocorticoid receptor ligands: Biochemical, pharmacological, and clinical aspects
W. Sutanto,E.R. de Kloet +1 more
Journal ArticleDOI
Cellular and molecular aspects of the renal effects of diuretic agents
TL;DR: Increased knowledge of the nature of transport proteins and their molecular regulation in the translocation of ions across kidney membranes has emerged and it is likely that this knowledge will permit further insight into nephron function regulation.
Journal ArticleDOI
Destruction of testicular cytochrome P-450 by 7α-thiospironolactone is catalyzed by the 17α-hydroxylase
TL;DR: The results indicate that the 17α-hydroxylase catalyzes the conversion of 7α-thio-SL to the reactive metabolite responsible for P-450 destruction, which supports the hypothesis that suicide inhibition is the mechanism involved.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
Journal ArticleDOI
Studies on the destruction of adrenal and testicular cytochrome P-450 by spironolactone. Requirement for the 7alpha-thio group and evidence for the loss of the heme and apoproteins of cytochrome P-450.
TL;DR: In viva or in vitro studies presented in this paper suggest that spironolactone or deacetylspironolactsone may be converted by cytochrome P-450 to an active metabolite which, in turn, destroys the heme of cyto Chrome P- 450, thereby decreasing steroid hydroxylase activities in the adrenal or in the testes.
Journal ArticleDOI
Spironolactone: Disposition, Metabolism, Pharmacodynamics, and Bioavailability
TL;DR: In this paper, Spironolactone: Disposition, Metabolism, Pharmacodynamics, and Bioavailability is discussed and a review of drug metabolism reviews is given, with a focus on drug metabolism.
Journal ArticleDOI
New insights into the pharmacokinetics of spironolactone.
TL;DR: This study demonstrated that 7α‐Thiomethylspirolactone is the main metabolite of spironolactone after a single oral dose as judged by the AUC(0–24) and the maximum concentration.
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