Journal ArticleDOI
Spectrofluorimetric study of porphyrin incorporation into membrane models - evidence for pH effects
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TLDR
The effects of hydrophobicity and charges of dicarboxylic porphyrins upon their interactions with membrane model systems are investigated and the hypothesis of a possible role of pH in the preferential uptake of p Morphyrins by tumors is discussed.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1986-05-28. It has received 105 citations till now. The article focuses on the topics: Porphyrin & Hematoporphyrin.read more
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Photophysical properties of porphyrinoid sensitizers non-covalently bound to host molecules; models for photodynamic therapy
TL;DR: In this paper, the binding of photosensitizers to host molecules is discussed from the perspective of how the confinement in a molecular assembly influences the sensitizer's photophysical properties.
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Photochemotherapy of cancer: experimental research.
Johan Emelian Moan,Kristian Berg +1 more
TL;DR: A combination of injection of a tumor localizing and photosensitizing dye and local exposure of the tumor region to light constitutes the basis for PCT.
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Photophysical properties of porphyrins in biological membranes.
TL;DR: Only monomeric species and possibly planar end-to-end aggregates are endowed with significant photosensitizing ability in porphyrin aggregation state, and many conclusions presented are based on data obtained on membrane model systems such as micelles or liposomes which can mimic specific situations occurring in cells.
Journal ArticleDOI
Acid-base properties of chlorin e6: relation to cellular uptake.
TL;DR: It is concluded that a change in the pH value of the surrounding medium leads to achange in the lipophilicity of chlorin e6, likely to influence its binding to the serum proteins as well as its interaction with the plasma membrane of cells and may also be related to the selective tumor uptake of the drug.
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The possible role of ionic species in selective biodistribution of photochemotherapeutic agents toward neoplastic tissue.
Roy H. Pottier,James C. Kennedy +1 more
TL;DR: A two-fold mechanism of selective biodistribution is advanced, one involving normal tissue vs. tumor tissue selectivity, the other involving intracellular vs. intercellular distribution of sensitizer ionic species.
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Journal Article
In Vitro Cellular Effects of Hematoporphyrin Derivative
Michael W. Berns,Anton Dahlman,Fred M. Johnson,Burns Rg,Daryn Sperling,Mark J. Guiltinan,A. Siemens,Robert J. Walter,William F Wright,Marie J. Hammer-Wilson,Alan G. Wile +10 more
TL;DR: HPD was shown to have a growth-inhibiting effect on rat kangaroo cells without added light and the growth effects on mouse cells were less marked.
Journal ArticleDOI
Effects of photoactivated porphyrins at the cell surface of leukemia L1210 cells.
TL;DR: The initial site of photoactivated porphyrin toxicity is at or near the cell surface, and this mode of action is confirmed in murine leukemia L1210 cells.