Stabilization of Curcumin by Complexation with Divalent Cations in Glycerol/Water System
TLDR
On evaluation of in vitro stability, all complexes were found to provide a higher stability from curcumin alone, compared to cur cumin alone.Abstract:
The purpose of present study was to stabilize curcumin food pigment by its complexation with divalent ions like (Zn(2+), Cu(2+), Mg(2+), Se(2+)), in "green media" and evaluate its stability in vitro compared to curcumin alone. The curcumin complexes were prepared by mechanical mixture of curcumin and sulfate salts of each metal (metal : curcumin 1/1mol) into unconventional and nontoxic glycerol/water solvent. Two stoichiometry of complex were obtained, 1 : 1 and 1 : 2 (metal/curcumin), respectively. On evaluation of in vitro stability, all complexes were found to provide a higher stability from curcumin alone.read more
Citations
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References
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Ying-Jan Wang,Min-Hsiung Pan,Ann-Lii Cheng,Liang-In Lin,Yuan Soon Ho,Chang-Yao Hsieh,Jen-Kun Lin +6 more
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TL;DR: In this paper, a timely and targeted release of food ingredients at the right place and the right time is provided by microencapsulation, which can improve the effectiveness of food additives, broaden the application range of ingredients and ensure optimal dosage, thereby improving cost effectiveness for the food manufacturer.
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TL;DR: It is proved that curcumin-phospholipid complex has better hepatoprotective activity, owe to its superior antioxidant property, than freeCurcumin at the same dose level.
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Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: solubility, chemical and photochemical stability
TL;DR: The hydrolytic stability of curcumin under alkaline conditions was strongly improved by complex formation, while the photodecomposition rate was increased compared to aCurcumin solution in organic solvents.
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Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models.
Larry Baum,Alex L K Ng +1 more
TL;DR: Curcumin might exert a net protective effect against Abeta toxicity or might suppress inflammatory damage by preventing metal induction of NF-kappaB.