Journal ArticleDOI
Stable Suppression of a Novel Oncogene, AHI-1, in Human Cutaneous T-Cell Leukemia Cells Normalizes Its Transforming Activity In Vitro and In Vivo and Aberrant Expression of AHI-1 Is Also Present in Leukemic Sezary Cells from Patients with Sezary Syndrome.
Ashley Ringrose,Youwen Zhou,Emily Pang,Ann Lin,Xiao-Jiang Li,Irene Li,Andrew P. Weng,Xiaoyan Jiang +7 more
TLDR
Findings provide strong evidence of the oncogenic activity of AHI-1 in human T-cell leukemic cells and its deregulation can contribute to the development of human cutaneous T- cell lymphomas, including Sezary syndrome.About:
This article is published in Blood.The article was published on 2005-11-16. It has received 188 citations till now. The article focuses on the topics: Sezary Cell & T-cell leukemia.read more
Citations
More filters
Journal ArticleDOI
Seven haemostatic gene polymorphisms in coronary disease : meta-analysis of 66 155 cases and 91 307 controls
Zheng Ye,Eugene H C Liu,Julian P T Higgins,Bernard Keavney,Gordon D.O. Lowe,Rory Collins,John Danesh +6 more
TL;DR: Meta-analyses on seven haemostatic genetic variants involved in the development of venous thrombosis found they might each be moderately associated with the risk of coronary disease, and explored potential sources of heterogeneity.
Journal ArticleDOI
Bleeding, Blood Transfusion, and Increased Mortality After Percutaneous Coronary Intervention: Implications for Contemporary Practice
TL;DR: The basis for a possible causal link between post-PCI bleeding and subsequent mortality is examined and possible mechanisms underpinning such a link are discussed, including a potential adverse role for blood transfusion in this setting.
Journal ArticleDOI
The central role of thrombin in hemostasis.
TL;DR: The context in which thrombin acts during hemostasis is described and the roles that its exosites and cofactors play in directing throm bin function are explained, and the concept of cofactor competition is developed.
Journal ArticleDOI
Blood coagulation: hemostasis and thrombin regulation.
TL;DR: This review focuses on the regulatory mechanisms of hemostasis and thrombin generation using multiple, simplified models of coagulation to help control bleeding without potentially increasing prothrombotic risks.
Journal ArticleDOI
Pathophysiology and Treatment of Coagulopathy in Massive Hemorrhage and Hemodilution
TL;DR: Fresh frozen plasma, platelet concentrate, and cryoprecipitate are considered the mainstay hemostatic therapies and Purified factor concentrates from recombinant synthesis are increasingly used for a rapid restoration of targeted factors.