Journal ArticleDOI
Standardizing procedures to study sensitization of human spinal nociceptive processes: comparing parameters for temporal summation of the nociceptive flexion reflex (TS-NFR).
Ellen L. Terry,Emily J. Bartley,Jennifer L. DelVentura,Kara L. Kerr,A. Vincent,Jamie L. Rhudy +5 more
TLDR
Discrepancies were noted between TS-NFR and TS-pain which raise concerns about using pain ratings to infer changes in spinal nociceptive processes, and some individuals did not have reliable NFRs when the stimulation intensity was set at NFR threshold during TS- NFR testing; therefore, a higher intensity is needed.About:
This article is published in International Journal of Psychophysiology.The article was published on 2011-09-01. It has received 41 citations till now. The article focuses on the topics: Nociceptive flexion reflex & Muscle tension.read more
Citations
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Journal ArticleDOI
Assessing pain objectively: the use of physiological markers
TL;DR: The most important developments in the field of objective markers of nociception or pain are introduced and shortcomings are highlighted to allow the reader to make informed decisions about what trends to watch in the future.
Journal ArticleDOI
Emotional modulation of pain and spinal nociception in fibromyalgia
Jamie L. Rhudy,Jennifer L. DelVentura,Ellen L. Terry,Emily J. Bartley,Ewa Olech,Shreela Palit,Kara L. Kerr +6 more
TL;DR: Results suggest that FM is associated with a disruption of supraspinal processes associated with positive affect and emotional modulation of pain, but not brain‐to‐spinal cord circuitry that modulates spinal nociceptive processes.
Journal ArticleDOI
Reflex receptive fields are enlarged in patients with musculoskeletal low back and neck pain
José Biurrun Manresa,Alban Y. Neziri,Alban Y. Neziri,Michele Curatolo,Lars Arendt-Nielsen,Ole Kæseler Andersen +5 more
TL;DR: It is demonstrated that musculoskeletal pain conditions are characterized by enlarged RRF, lowered NWR and pain thresholds, and facilitated temporal summation, most likely caused by widespread spinal hyperexcitability.
Journal ArticleDOI
Reliability of Quantitative Sensory Tests in a Low Back Pain Population
Pascal Henri Vuilleumier,José Biurrun Manresa,Yassine A. Ghamri,Sabine Mlekusch,Andreas Siegenthaler,Lars Arendt-Nielsen,Michele Curatolo +6 more
TL;DR: Most QST measurements have acceptable reliability in patients with chronic low back pain, and exceptions were cold pain detection thresholds at the leg and arm.
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Emotional modulation of pain and spinal nociception in persons with major depressive disorder (MDD).
TL;DR: Emotional modulation of pain deficits may be a phenotypic marker for future pain risk in MDD, as evidenced by a blunted pleasure response to erotica and a failure to modulate startle according to a valence linear trend.
References
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Evidence for a central component of post-injury pain hypersensitivity
TL;DR: An animal model is developed where changes occur in the threshold and responsiveness of the flexor reflex following peripheral injury that are analogous to the sensory changes found in man, and shows that it in part arises from changes in the activity of the spinal cord.
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Physiological Properties of Unmyelinated Fiber Projection to the Spinal Cord
TL;DR: It was suggested that the C fiber input produced the increase in dynamic range and that this accounted for the involvement of unmyelinated fibers in high threshold phenomena (e.g., pain).
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Evidence for involvement of N-methylaspartate receptors in 'wind-up' of class 2 neurones in the dorsal horn of the rat
Stephen N. Davies,David Lodge +1 more
TL;DR: N-Methylaspartate receptors appear to contribute to the wind-up, but not the initial response, of class 2 neurones in the rat, while Iontophoretic or intravenous ketamine had no consistent effect on theInitial response but consistently reduced wind- up.
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Peripheral suppression of first pain and central summation of second pain evoked by noxious heat pulses
TL;DR: The relationship between first and second pain and impulse conduction in A&dgr; and C noxious heat afferents, respectively and previous studies have shown that wide dynamic range dorsal horn neurons show summated responses to repeated volleys in C fibers could account for the summation of second pain.