Journal ArticleDOI
Stimulation of neuronal acetylcholine receptors induces rapid gene transcription
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TLDR
It is suggested that neurotransmitters may rapidly activate specific gene transcription in nondividing neuronally differentiated cells and a functional role for neurotransmitter induction of c-fos and actin expression in the nervous system is suggested.Abstract:
Cholinergic agonists rapidly and transiently induced transcription of the c-fos protooncogene and one or more actin genes in neuronally differentiated PC12 cells. Transcription was activated within minutes after stimulation of the nicotinic acetylcholine receptor and required an influx of extracellular Ca2+ ions through voltage-sensitive calcium channels. Nicotine activation proceeded by a different pathway from activation by nerve growth factor, whose stimulation of these genes is independent of extracellular Ca2+ ions. These findings suggest that neurotransmitters may rapidly activate specific gene transcription in nondividing neuronally differentiated cells. They also suggest a functional role for neurotransmitter induction of c-fos and actin expression in the nervous system.read more
Citations
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Function and Regulation of CREB Family Transcription Factors in the Nervous System
Bonnie E. Lonze,David D. Ginty +1 more
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References
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Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.
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Stimulation of 3T3 cells induces transcription of the c- fos proto-oncogene
TL;DR: Transcription of the c-fos proto-oncogene is greatly increased within minutes of administering purified growth factors to quiescent 3T3 cells, and this stimulation is the most rapid transcriptional response to peptide growth factors yet described, implying a role for c- fos in cell-cycle control.
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Cell-Specific Regulation of the c-myc Gene by Lymphocyte Mitogens and Platelet-Derived Growth Factor
TL;DR: A regulatory linkage between the function of two oncogenes--c-myc and c-sis--the latter being the putative structural gene for PDGF is suggested, consistent with a model that a labile protein may regulate c- myc levels in these cells.
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Induction of c- fos gene and protein by growth factors precedes activation of c- myc
TL;DR: Stimulation of fibroblasts with serum or purified growth factors leads to a dramatic induction of expression of both c-fos mRNA and protein within a few minutes, followed by activation of c-myc.
Journal ArticleDOI
Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein
TL;DR: Exposure of quiescent mouse fibroblasts to platelet-derived growth factor induces mRNA from the c-fos proto-oncogene within 10 min followed by synthesis of nuclear c- fos proteins, amongst the earliest described nuclear events that follow a mitogenic stimulus.