Stockpiling of Transitional and Classic Primary Follicles in Ovaries of Women with Polycystic Ovary Syndrome
Gustavo Arantes Rosa Maciel,Edmund Chada Baracat,Jo Ann Benda,Sanford M. Markham,Krista Hensinger,R. Jeffrey Chang,Gregory F. Erickson +6 more
TLDR
It is concluded that primary follicle growth is abnormally slow in PCOS and the dynamics are reflected in a stockpiling of classic primary follicles.Abstract:
Recently, we proposed an oocyte-growth differentiation factor-9 hypothesis that predicts alterations in the initial stages of folliculogenesis in polycystic ovary syndrome (PCOS) ovaries. Here, we test this hypothesis by scoring the composition of follicles in normal and PCOS ovaries. Follicles were classified as primordial, transitional primary, classic primary, secondary, and Graafian. A total of 2274 follicles were scored. The total number of growing follicles was significantly greater in PCOS ovaries than normal, but the number of nongrowing primordial follicles did not differ. Consequently, the increase in growing follicles in PCOS cannot be explained by increased primordial follicle recruitment. Differential counts showed that the number of growing follicles at each stage of development was significantly greater: PCOS had 2.7-fold more primary, 1.8-fold more secondary, and 2-fold more Graafian follicles than normal. The greatest effect was on the classic primary follicles where the number was almost...read more
Citations
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Journal ArticleDOI
Polycystic ovary syndrome.
Ricardo Azziz,Enrico Carmina,Zi-Jiang Chen,Andrea Dunaif,Joop S.E. Laven,Richard S. Legro,Daria Lizneva,Daria Lizneva,Barbara Natterson-Horowtiz,Helena J. Teede,Bulent O. Yildiz +10 more
TL;DR: PCOS can impact women’s reproductive health, leading to anovulatory infertility and higher rate of early pregnancy loss, and the risks of diabetes, cardiovascular disease, hypertension, metabolic syndrome, and endometrial cancer among PCOS patients are significantly increased.
Book
Polycystic Ovary Syndrome
TL;DR: It is of interest to realize that polycystic ovary syndrome has moved from a histology diagnosis of ovarian tissue to a heterogeneous clinical syndrome, to a reproductive endocrine abnormality with elevated serum luteinizing hormone and androgen levels, and to a metabolic disease characterized by hyperinsulinemia and dyslipidemia.
Journal ArticleDOI
The physiology and clinical utility of anti-Müllerian hormone in women
Didier Dewailly,Claus Yding Andersen,Adam H. Balen,Frank J. M. Broekmans,Nafi Dilaver,Renato Fanchin,Georg Griesinger,Tom Kelsey,Antonio La Marca,C.B. Lambalk,Helen D. Mason,Scott M. Nelson,Jenny A. Visser,W. Hamish B. Wallace,Richard A. Anderson +14 more
TL;DR: There is a linear relationship between AMH and oocyte yield after ovarian stimulation, which is of value in predicting ovarian hyperstimulation, and the submerged part of the iceberg of follicle growth, i.e. the intrinsic, so-called 'acyclic' ovarian activity is measured.
Journal ArticleDOI
Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome
Daniel A. Dumesic,Sharon E. Oberfield,Elisabet Stener-Victorin,John C. Marshall,Joop S.E. Laven,Richard S. Legro +5 more
TL;DR: The pathophysiology involves abnormal gonadotropin secretion from a reduced hypothalamic feedback response to circulating sex steroids, altered ovarian morphology and functional changes, and disordered insulin action in a variety of target tissues.
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