Journal ArticleDOI
Stress granules: the Tao of RNA triage
Paul A. Anderson,Nancy Kedersha +1 more
TLDR
Although both self-assemble in response to stress-induced perturbations in translation, several recent reports reveal novel proteins and RNAs that are components of these structures but also perform other cellular functions.About:
This article is published in Trends in Biochemical Sciences.The article was published on 2008-03-01. It has received 1024 citations till now. The article focuses on the topics: Stress granule & P-bodies.read more
Citations
More filters
Journal ArticleDOI
Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
TL;DR: Recent advances in understanding of the molecular structures and biochemical functions of the translation initiation machinery are described and key strategies that mediate general or gene-specific translational control are summarized, particularly in mammalian systems.
Journal ArticleDOI
MicroRNA and cancer.
Martin D. Jansson,Anders H. Lund +1 more
TL;DR: The current knowledge and concepts concerning the involvement of microRNAs in cancer, which have emerged from the study of cell culture and animal model systems, including the regulation of key cancer‐related pathways, such as cell cycle control and the DNA damage response are summarized.
Journal ArticleDOI
Protein arginine methyltransferases and cancer.
Yanzhong Yang,Mark T. Bedford +1 more
TL;DR: There are nine protein arginine methyltransferases (PRMTs) encoded in mammalian genomes, the protein products of which catalyse three types of ARG modifications: monomethylation and two types of dimethylation as discussed by the authors.
Journal ArticleDOI
RNA granules: post-transcriptional and epigenetic modulators of gene expression
Paul A. Anderson,Nancy Kedersha +1 more
TL;DR: It is proposed that RNA granules can be both a cause and a consequence of altered mRNA translation, decay or editing and serve as key modulators of post-transcriptional and epigenetic gene expression.
Journal ArticleDOI
MicroRNA functions in stress responses.
TL;DR: This work has shown that miRNAs play key roles in fundamental cellular processes, including how cells respond to changes in environment or stresses, and dysregulation of these processes contributes to chronic diseases, including cancers.
References
More filters
Journal ArticleDOI
Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells
Heather P. Harding,Isabel Novoa,Yuhong Zhang,Huiqing Zeng,Ronald C. Wek,Matthieu Schapira,David Ron +6 more
TL;DR: Protein kinases that phosphorylate the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha) are activated in stressed cells and negatively regulate protein synthesis, resulting in the induction of the downstream gene CHOP (GADD153).
Journal ArticleDOI
Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response
TL;DR: In this paper, the authors report that mutating the gene encoding the ER stress-activated eIF2alpha kinase PERK abolishes the phosphorylation of eIF 2 alpha in response to accumulation of malfolded proteins in the ER resulting in abnormally elevated protein synthesis and higher levels of ER stress.
Journal ArticleDOI
Stress granules and processing bodies are dynamically linked sites of mRNP remodeling
Nancy Kedersha,Georg Stoecklin,Maranatha Ayodele,Patrick W. Yacono,Jens Lykke-Andersen,Marvin J. Fritzler,Donalyn Scheuner,Randal J. Kaufman,David E. Golan,Paul A. Anderson +9 more
TL;DR: It is proposed that mRNA released from disassembled polysomes is sorted and remodeled at SGs, from which selected transcripts are delivered to PBs for degradation, an interaction that is promoted by the related mRNA decay factors TTP and BRF1.
Journal ArticleDOI
P Bodies and the Control of mRNA Translation and Degradation
TL;DR: An emerging model of cytoplasmic mRNA function is suggested in which the rates of translation and degradation of mRNAs are influenced by a dynamic equilibrium between polysomes and the mRNPs seen in P bodies.
Journal ArticleDOI
Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing Bodies
Ujwal Sheth,Roy Parker +1 more
TL;DR: The flux of mRNAs between polysomes and P bodies is defined as a critical aspect of cytoplasmic mRNA metabolism and a possible site for regulation of mRNA degradation.