Journal ArticleDOI
Stress response patterns of plasma corticosterone, prolactin, and growth hormone in the rat, following handling or exposure to novel environment.
Jo Seggie,Gregory M. Brown +1 more
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TLDR
This study confirms that hormone responses to stress are complex and depend not only on the stimulus but the context of stimulation.Abstract:
Corticosterone, prolactin, and growth hormone responses to 5 s of handling or 3 min of novel environment were compared in rats at crest and trough of the diurnal adrenal rhythm 0, 5, 15, 30, and 60 min after stimulation. All hormones responded to stimulation, corticosterone and prolactin with a dramatic rise, and growth hormone with a precipitous fall. Resting corticosterone levels evidenced the expected diurnal variation, and prolactin but not growth hormone also showed a baseline diurnal variation of small magnitude at the times studied. Growth hormone response characteristics were unaffected by time of day or type of stimulation. Both corticosterone and prolactin response profiles differed at both times of day and following both types of stimulation. Corticosterone and prolactin levels were highly correlated and each was negatively correlated with growth hormone levels. This study confirms that hormone responses to stress are complex and depend not only on the stimulus but the context of stimulation.read more
Citations
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Fear and fearfulness in animals.
TL;DR: The great variability in behavior and in physiological patterns generally associated with emotional reactivity is described, suggesting that fearfulness could be considered a basic feature of the temperament of each individual, one that predisposes it to respond similarly to a variety of potentially alarming challenges but is nevertheless continually modulated during development by the interaction of genetic traits of reactivity with environmental factors, particularly in the juvenile period.
Journal Article
Laboratory routines cause animal stress.
TL;DR: The data suggest that significant fear, stress, and possibly distress are predictable consequences of routine laboratory procedures, and that these phenomena have substantial scientific and humane implications for the use of animals in laboratory research.
Journal ArticleDOI
Effects of housing on male and female rats: Crowding stresses males but calms females
Kelly J. Brown,Neil E. Grunberg +1 more
TL;DR: Results indicate that investigators must consider housing conditions as an intervening variable that is likely to differentially affect behaviors of male and female rats.
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Anxiolytic and Anti-Stress Effects of Brain Prolactin: Improved Efficacy of Antisense Targeting of the Prolactin Receptor by Molecular Modeling
TL;DR: Evidence is provided for a receptor-mediated attenuation of the responsiveness of the hypothalamo-pituitary-adrenal (HPA) axis by prolactin as a novel regulator of both emotionality and HPA axis reactivity.
Journal ArticleDOI
Prenatal stress: effects on brain biogenic amine and plasma corticosterone levels.
TL;DR: It is suggested that changes in the development of specific monoamine-containing neurons may be associated with the reported behavioral deficits in offspring of female rats stressed during pregnancy.
References
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Book
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TL;DR: In this article, the authors introduce the principles of estimation and inference: means and variance, means and variations, and means and variance of estimators and inferors, and the analysis of factorial experiments having repeated measures on the same element.
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TL;DR: In this paper, the main text for an upper-level undergraduate or graduate-level introductory statistics course in departments of psychology, educational psychology, education and related areas is presented. But the course is not designed for the general public.
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Some Studies of the Protein-Binding of Steroids and Their Application to the Routine Micro and Ultramicro Measurement of Various Steroids in Body Fluids by Competitive Protein-Binding Radioassay
TL;DR: A 100-fold increase in sensitivity has now been achieved by using tritiated steroids in place of 14C-labeled steroids, by utilizing the CBG's of species other than man, and by using adsorption in Place of dialysis or gel filtration.
Journal ArticleDOI
Twenty-four Hour Pattern of the Episodic Secretion of Cortisol in Normal Subjects
Elliot D. Weitzman,David K. Fukushima,Christopher Nogeire,Howard P. Roffwarg,T. F. Gallagher,Leon Hellman +5 more
TL;DR: Although great variability was found in both the amount of cortisol secreted and the time spent in secretory activity/hr, the secretory rate was quite constant at approximately .05 mg/min.
Journal ArticleDOI
A review of psychoendocrine research on the pituitary-adrenal cortical system.
TL;DR: There is no longer room for reasonable doubt as to the validity of the basic conclusion that psychological stimuli are capable of influencing the level of pituitary‐adrenal cortical activity, and the general biological conclusions emerging from the work covered in this review may be summarized.