Journal ArticleDOI
Structural biology and chemistry of the terpenoid cyclases.
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This article is published in Chemical Reviews.The article was published on 2006-06-01. It has received 665 citations till now.read more
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Glycosyltransferases: structures, functions, and mechanisms.
TL;DR: The expected two-step double-displacement mechanism is rendered less likely by the lack of conserved architecture in the region where a catalytic nucleophile would be expected, and a mechanism involving a short-lived oxocarbenium ion intermediate now seems the most likely, with the leaving phosphate serving as the base.
Journal ArticleDOI
The family of terpene synthases in plants: A mid-size family of genes for specialized metabolism that is highly diversified throughout the kingdom
TL;DR: The terpene synthases (TPSs) as mentioned in this paper are a family of enzymes responsible for the synthesis of various terpenes from two isomeric 5-carbon precursor molecules, leading to 5-carbinear isoprene, 10-carbon monoterpenes, 15-carbon sesquiterpenes and 20-carbenes.
Journal ArticleDOI
Monoterpene and sesquiterpene synthases and the origin of terpene skeletal diversity in plants.
TL;DR: This review covers the monoterpene and sesquiterpene synthases presenting an up-to-date list of enzymes reported and evidence for their ability to form multiple products.
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Cation-π interaction: its role and relevance in chemistry, biology, and material science.
References
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Journal ArticleDOI
Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia.
Journal ArticleDOI
Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and Trp
TL;DR: A great deal of direct and circumstantial evidence indicates that cation-π interactions are important in a variety of proteins that bind cationic ligands or substrates.
Journal ArticleDOI
Plant terpenoid synthases: Molecular biology and phylogenetic analysis
TL;DR: This review focuses on the monoterpene, sesquiterpenes, and diterpene synthases of plant origin that use the corresponding C10, C15, and C20 prenyl diphosphates as substrates to generate the enormous diversity of carbon skeletons characteristic of the terpenoid family of natural products.
Journal ArticleDOI
Structural Basis for Cyclic Terpene Biosynthesis by Tobacco 5-Epi-Aristolochene Synthase
Courtney M. Starks,Kyoungwhan Back,Kyoungwhan Back,Joseph Chappell,Joseph Chappell,Joseph P. Noel,Joseph P. Noel +6 more
TL;DR: These structures reveal an unexpected enzymatic mechanism for the synthesis of the bicyclic product, 5-epi-aristolochene, and provide a basis for understanding the stereochemical selectivity displayed by other cyclases in the biosynthesis of pharmacologically important cyclic terpenes.