Journal ArticleDOI
Structural Studies of Crystalline Enamines
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TLDR
In this paper, crystal structure analyses of five crystalline enamines together with recently published structural data for two other enamines reveal varying degree of pyramidality at the enamine nitrogen atom.Abstract:
Crystal structure analyses of five crystalline enamines together with recently published structural data for two other enamines reveal varying degree of pyramidality at the enamine nitrogen atom. The pyramidality appears to be most pronounced in enamines from piperidine and morpholine, less so in enamines derived from prolinoid amines. A pyrolidine enamine obtained from a derivative of cyclohexane-1,4-dione seems to have a virtually planar enamine group. The implications of these findings for current stereochemical problems in enamine chemistry are discussed.read more
Citations
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Journal ArticleDOI
Asymmetric enamine catalysis.
Journal ArticleDOI
Asymmetric aminocatalysis--gold rush in organic chemistry.
TL;DR: This Review describes this "Asymmetric Aminocatalysis Gold Rush" and charts the milestones in its development.
Journal ArticleDOI
Lewis Base Catalysis in Organic Synthesis
TL;DR: It has become increasingly apparent that the behavior of Lewis bases as agents for promoting chemical reactions is not merely as an electronic complement of the cognate Lewis acids: in fact Lewis bases are capable of enhancing both the electrophilic and nucleophilic character of molecules to which they are bound.
Journal ArticleDOI
Structure and Reactivity of Lithium Enolates. From Pinacolone to Selective C‐Alkylations of Peptides. Difficulties and Opportunities Afforded by Complex Structures
TL;DR: The chemistry of lithium enolates is used to demonstrate that complex structures held together by noncovalent bonds (supramolecules) may dramatically influence the result of seemingly simple standard reactions of organic synthesis as mentioned in this paper.
References
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Journal ArticleDOI
The Enamine Alkylation and Acylation of Carbonyl Compounds
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On the rigid-body motion of molecules in crystals
V. Schomaker,K. N. Trueblood +1 more
Journal ArticleDOI
Geometrical reaction coordinates. II. Nucleophilic addition to a carbonyl group
Journal ArticleDOI
Stereochemistry of reaction paths at carbonyl centres
TL;DR: In this article, the reaction paths found by different methods for different nucleophiles show some striking similarities that appear to be characteristic for the reaction type, and the results of recent experimental and theoretical studies of nucleophilic addition to carbonyl groups are described.
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