Journal ArticleDOI
Structure of antitumor agents 2-acetylpyridinethiosemicarbazone hemihydrate and 2-acetylpyridinethiosemicarbazone hydrochloride
TLDR
The structures of two antitumor agents, 2-acetylpyridinethiosemicarbazone hemihydrate (1), C18H11N4O0.5S, colorless,M�� r�� 203.085 as mentioned in this paper, have been determined.Abstract:
The structures of two antitumor agents, 2-acetylpyridinethiosemicarbazone hemihydrate (1), C18H11N4O0.5S, colorless,M
r
203.3, monoclinic,P21
lc,a=16.713(3),b=9.460(2),c=12.642(2) A, β=97.60(1)°,V=1981.2(6) A3,Z=8,R=0.054,R
w
=0.085 and 2-acetylpyridinethiosemicarbazone hydrochloride (2), C18H12N4SCl, yellow,M
r
=230.7, monoclinic,P21
ln,a=7.676(2),b=7.889(1),c=17.452(4), A, β=100.96(2)°,V=1037.5(4) A3
Z=4,R=0.041,R
w
=0.076, have been determined. Both compounds exhibit an E configuration(S atomtrans to the N atom of the hydrazine group). Three hydrogen bonds link the two crystallographically independent molecules in a pairwise fashion in the hemihydrate. An intramolecular N−H...Cl bond lends extra conformational stability to the hydrochloride salt.read more
Citations
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Journal ArticleDOI
Platinum(II) complexes with 2-acetyl pyridine thiosemicarbazone. Synthesis, crystal structure, spectral properties, antimicrobial and antitumour activity.
Dimitra Kovala-Demertzi,Mavroudis A. Demertzis,John R. Miller,Cryshanthi Papadopoulou,Catherine Dodorou,Giorge Filousis +5 more
TL;DR: Among these compounds, the most effective in inducing antitumour and cytogenetic effects are the complexes [Pt(AcTsc)(2)] and [Pd(Ac tsc)( 2)] while the rest, display marginal cytogenetics and antitumours effects.
Journal ArticleDOI
2-Acetylpyridine Thiosemicarbazones are Potent Iron Chelators and Antiproliferative Agents: Redox Activity, Iron Complexation and Characterization of their Antitumor Activity
Des R. Richardson,Danuta S. Kalinowski,Vera Richardson,Philip C. Sharpe,David B. Lovejoy,Mohammad Islam,Paul V. Bernhardt +6 more
TL;DR: This investigation generated the related 2-acetylpyridine thiosemicarbazone (HApT) analogues to examine the influence of the methyl group at the imine carbon and identified structural features necessary to form Fe complexes with potent anticancer activity.
Journal ArticleDOI
Mn(II), Co(II) and Zn(II) complexes with heterocyclic substituted thiosemicarbazones: synthesis, characterization, X-ray crystal structures and antitumor comparison.
TL;DR: Preliminary in vitro screening indicated that all the tested compounds showed significant antitumor activity against K562 leucocythemia cancer cell line.
Journal ArticleDOI
Synthesis, characterization and crystal structure of cobalt(III) complexes containing 2-acetylpyridine thiosemicarbazones: DNA/protein interaction, radical scavenging and cytotoxic activities.
Rajendran Manikandan,Periasamy Viswanathamurthi,K. Velmurugan,Raju Nandhakumar,Takeshi Hashimoto,Akira Endo +5 more
TL;DR: In vitro cytotoxicity of the cobalt(III) complexes against MCF-7 and A431 cell lines was assayed which showed higher activity and efficiently vanished the cancer cells even at low concentrations.
Journal ArticleDOI
Compositional and structural variety of diphenyllead(IV) complexes obtained by reaction of diphenyllead dichloride with thiosemicarbazones.
José S. Casas,Eduardo E. Castellano,Javier Ellena,Maria S. Garcia Tasende,Agustín Sánchez,José Sordo,María J. Vidarte +6 more
TL;DR: The reactions of PbPh( 2)Cl(2) in methanol with acetophenone, salicylaldehyde, pyridine-2-carbaldehyde, 2-acetylpyridine, and 2-benzoylpyridine thiosemicarbazones were explored and the compositions of these solutions were investigated using conductivity measurements and (1)H and (207)Pb NMR spectroscopy.
References
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Book
International tables for X-ray crystallography
Norman Fordyce McKerron Henry,Lonsdale, Kathleen, Dame,John S. Kasper,Caroline H. MacGillavry,Gerard D. Rieck,James A. Ibers,Walter C. Hamilton +6 more
Book ChapterDOI
Structural and physical correlations in the biological properties of transition metal heterocyclic thiosemicarbazone and S -alkyldithiocarbazate complexes
TL;DR: The nature of metal complexes of heterocyclic thiosemicarbazones reported in the literature through 1989 have been reviewed with an emphasis on variations in stoichiometry and stereochemistry as discussed by the authors.
Journal ArticleDOI
2-Acetylpyridine thiosemicarbazones. 4. Complexes with transition metals as antimalarial and antileukemic agents.
TL;DR: These complexes show reduced antimalarial activity in mice infected with Plasmodium berghei; however, antileukemic properties are enhanced by coordination with the above-mentioned metals.
Journal ArticleDOI
2-Acetylpyridine thiosemicarbazones. 5. 1-[1-(2-Pyridyl)ethyl]-3-thiosemicarbazides as potential antimalarial agents.
TL;DR: Compound 7, 3-azabicyclo[3.2.2]nonane-3-carbothioic acid 2-[1-(2-pyridyl)ethyl]hydrazide, is the most potent derivative of 2-acetylpyridine to date, and the enhancement of activity was accompanied by an increase in toxicity.