Showing papers in "Journal of Inorganic Biochemistry in 2001"

TL;DR: In this article, two complexes of [Co(phen)2IP]3+ (IP=imidazo[4,5-f][1,10]phenanthroline) and [Co-(phen) 2PIP] 3+ (PIP=2-phenylimidazo [4, 5-f], 1,10]-phenanthropyline) have been synthesized and characterized by UV/VIS, IR, EA and mass spectra.

TL;DR: Eight rare earth metal(II) complexes with quercetin ML3 x 6H2O have been synthesized and characterized by elemental analysis, complexometric titration, thermal analysis, conductivity, IR, UV, 1HNMR and fluorescence spectra techniques as well as cyclic voltammetry.

TL;DR: Among these compounds, the most effective in inducing antitumour and cytogenetic effects are the complexes [Pt(AcTsc)(2)] and [Pd(Ac tsc)( 2)] while the rest, display marginal cytogenetics and antitumours effects.

TL;DR: The quantitative description of these complexes in solution and the solid state provides the basis for predictions of interference from DTT in studies of metal ion binding of thiol-containing biomolecules.

TL;DR: To investigate the relationship between antimicrobial activities and the molecular structures of nickel(II) complexes with thiosemicarbazone and semicarbazones ligands, nickel( II) complexesWith ligands Hmtsc, Hatsc, Hasc and H2dmtsc were prepared and characterized by elemental analysis, FT-IR, 1H and 13C NMR spectroscopies, magnetic susceptibility measurements, UV-Vis absorption spectra, TG/DTA and single

TL;DR: VOSO(4) and VO(malto)(2) showed differences when levels of plasma glucose and blood V in diabetic rodents were compared, and in the formation of V-protein complexes with abundant serum proteins, which suggest that binding of V compounds to ligands in blood, such as proteins, may affect the available pool of V for biological effects.

TL;DR: It is demonstrated that as with CO, perturbation of the heme environment by NO is communicated to the active site with concomitant inhibition of enzyme activity, and suggests a regulatory role for heme in cystathionine beta-synthase.

TL;DR: The kinetics and mechanisms of the reactions of a number of pyrogallol-based ligands with iron(III) have been investigated in aqueous solution and Mechanisms have been proposed which account satisfactorily for the kinetic data.

TL;DR: In an animal model of aluminum overload, the increases in tissue aluminium content were paralleled by elevations of tissue iron in the kidney, liver heart and spleen as well as in various brain regions, frontal, temporal and parietal cortex and hippocampus, supporting previous studies which found little evidence for aluminium storage within ferritin.

TL;DR: The available evidence supports an increasing antimicrobial effeciency for the cationic complexes, and the crystal structure of bis(1,10-phenanthroline)(2-methyl-4-chloro-phenoxyacetato)copper(ll) chloride-methanol(1/1)-water (1/0.6), 1 has been determined and refined by least-squares methods using three-dimensional MoK, data.

TL;DR: Electronic spectra, magnetic susceptibility measurements and EPR spectra of the synthesised complexes indicate a tetragonal environment.

TL;DR: The results of the studies on several recombinant NHases have shown that the Cys-SO2H oxidation of alphaC112 is indispensable for the catalytic activity of Fe-type NHase.

TL;DR: The [M(ESDT)Cl]n species have been reacted with various amines in dichloromethane or chloroform to obtain mixed ligand complexes and the dithiocarbamato intermediates have been tested for in vitro cytostatic activity against human leukemic HL-60 and HeLa cells.

TL;DR: The experimental results show that silybin binds Fe(III) even at acidic pH, which shows the possible role of sily bin in relation to the chelation therapy of chronic iron overload, as occurs in the treatment of Cooley's anemia.

TL;DR: Both complexes have been found to promote the photocleavage of plasmid pBR 322 DNA, the hydroxyl radical (OH*) is suggested to be the reactive species responsible for the cleavage.

TL;DR: Biological studies of [Ni(M5HFTSC)(2)Cl(2)] have been carried out in vitro for antifungal activity on human pathogenic fungi, Aspergillus fumigatus and Candida albicans, and in vivo for toxicity on mice.

TL;DR: Some new rapid low temperature routes using hydrazines to labile Re(V) and Re(III) species which provide potential convenient access to a wide range of oxo- and diazenido-complexes are described.

TL;DR: The catecholase activity of complexes for the oxidation of 3,5-di-tert-butylcatechol by O2 was studied and it was found that the complexes with the bond distance of Cu(II)...Cu(II) located at 2.9-3.0 A show higher catechlase activity.

TL;DR: Three new complexes of transition metals as copper, nickel and cobalt with 5-formyluracil thiosemicarbazone (H3ut) have been synthesised and characterised by single-crystal X-ray diffraction and demonstrated low activity in cell growth, while the copper complex that is more active has been tested also on a third leukemic human cell line (U937), but it was not able to induce apoptosis on all cell lines.

TL;DR: A structure-activity correlation using Extended-Hückel MO calculations is described and the observed order of cytotoxicity against melanoma B16F10 and Friend erythroleukemia cells is: 1< or =ligand<2<3.

TL;DR: Comparing the fluorescence and IR spectral results for all three class A metals, it seems clear that major sources of the deviation in spectral properties between Al(3+) and Ca(2+)/Tb(3+) is the unusually high value of its charge density and relatively low propensity for involvement in covalent bonding interactions.

TL;DR: The presence of L-methionine resulted in a different kind of adduct formation which involves ammine release due to the trans-effect of sulfur and the time-dependent behavior of the reaction with 5'-GMP changed significantly.

TL;DR: The ability of antitumor active metallocenes Cp2MCl2 and the biologically inactive derivative (MeCp)2TiCl2, to inhibit the relaxation of supercoiled plasmid DNA pBR322 by human topoisomerase II has been studied by gel electrophoresis.

TL;DR: Tests on cell proliferation of human leukemic cell line U937 showed that the copper complex Cu(Et-mpt)Cl x H2O is the most active compound among those reported even though it is not able to induce apoptosis.

TL;DR: Oral administration in vivo experiments on the blood glucose level of streptozotocin-induced diabetes mice and the insulin-mimetic effects of metal-oxide clusters of all-inorganic composition suggest that not only monomeric tungstate and vanadate, but also the structure factors of tung state andVanadate clusters, can play a significant role in their biological action.

TL;DR: Localization of CYP51 mutation hotspots in Candida albicans azole resistant isolates was analyzed with respect to SRSs and mutations found to be outside of the putative substrate interacting sites indicating the preservation of the protein active site under the pressure of azole treatment.

TL;DR: One of the important mechanisms responsible for the cytotoxicity of cytokinin-derived compounds, the inhibition of cyclin-dependent kinases by the studied complexes, was also determined.

TL;DR: It is inferred that a conformation transition may occur due to the binding of the first Co(II) ion with the peptide segment of N-terminal residues 1-3, which results in a 'hinged movement' of the relatively hydrophobic 'valley' in the IA subdomain, which leads to a slow conformational transition in the albumins.

TL;DR: In a wide pH (including physiological) range the mouse fragments of beta-amyloid peptide are much more effective in Cu(II) binding than the human fragments, and the coordination of the amide nitrogen of Ala(2) is suggested.

TL;DR: Results of systematic studies on the formation of aluminium polycations at room temperature are reported and an alternative mechanism of aluminium ion polycondensation is proposed, based on the increased stability of monomeric and oligomeric species (dimer and trimer) in the presence of sulphate-ions.