Studies Toward the Subcortical Pathogenesis of Schizophrenia
Reads0
Chats0
TLDR
The importance of subcortical structures as they may be related to information processing and the life experience of schizophrenic patients is addressed, in a heuristic exercise aimed at bridging the conceptual gaps between clinical and research approaches to schizophrenia.Abstract:
In addition to introducing the six articles joined by our thematic outlook, this article addresses the importance of subcortical structures as they may be related to information processing and the life experience of schizophrenic patients. This is a heuristic exercise aimed at bridging the conceptual gaps between clinical and research approaches to schizophrenia. A brief overview is then provided of current conceptualizations of a number of subcortical structures, each of which may play a part in the subcortical pathogenesis of schizophrenia in specific patients. The central concepts are failures in the "automaticity" with which prior experience may be recreated in parallel with current stimulus input in schizophrenia (with concomitant failures in future orientation or contextually generated expectancy), and the view of subcortical structures as constituting a "system" in which no single type of defect may be common to all schizophrenic patients.read more
Citations
More filters
Journal ArticleDOI
The neuropsychology of schizophrenia.
TL;DR: A model is proposed for integrating the neural and cognitive aspects of the positive symptoms of acute schizophrenia, using evidence from postmortem neuropathology and neurochemistry, clinical and preclinical studies of dopaminergic neurotransmission, anatomical connections between the limbic system and basal ganglia, attentional and other cognitive abnormalities underlying the positive Symptoms of schizophrenia.
Journal ArticleDOI
Creativity and Personality: Suggestions for a Theory
TL;DR: In this paper, a causal chain is suggested reaching from DNA to creative achievement, based largely on experimental findings not usually considered in relation to creativity (e.g., latent inhibition) and the model is testable and hence may prove useful in not only accounting for many observations and experimental results but also in suggesting new experiments and observations.
Journal ArticleDOI
Automatic and effortful processing in depression.
TL;DR: The effortful-automatic perspective has implications for understanding depressive clinical features, treating depression, and conducting future research.
Journal ArticleDOI
Convergence of biological and psychological perspectives on cognitive coordination in schizophrenia
TL;DR: It is concluded that impaired cognitive coordination due to reduced ion flow through NMDA-channels is involved in schizophrenia, and it is suggested that it may also be involved in other disorders.
Journal ArticleDOI
The nature of learning and memory impairments in schizophrenia.
Jane S. Paulsen,Robert K. Heaton,Joseph Sadek,William Perry,Dean C. Delis,David L. Braff,Julie Kuck,Sidney Zisook,Dilip V. Jeste +8 more
TL;DR: Results suggest that most SC patients demonstrate a pattern of learning and memory impairments that resembles the pattern seen in patients with primary subcortical (specifically striatal) pathology.
References
More filters
Book
The Hippocampus as a Cognitive Map
John O'Keefe,Lynn Nadel +1 more
TL;DR: The amnesic syndrome is presented as an extension of the theory to humans and the role of operators in the locale system is examined.
Book
Perception and communication
TL;DR: In this paper, the authors describe a transition between behaviourist learning theory and the modern information processing or cognitive approach to perception and communication skills, and provide a principal starting point for theoretical and experimental work on selective attention.
Journal ArticleDOI
Controlled and automatic human information processing: I. Detection, search, and attention
Journal Article
Controlled and Automatic Human Information Processing: 1. Detection, Search, and Attention.
TL;DR: A series of studies using both reaction time and accuracy measures is presented, which traces these concepts in the form of automatic detection and controlled, search through the areas of detection, search, and attention and resolves a number of apparent conflicts in the literature.