Journal ArticleDOI
Studies with the Amine Adducts of β-Benzoylacrylic Acid and its Methyl Ester1
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This article is published in Journal of the American Chemical Society.The article was published on 1956-09-01. It has received 27 citations till now. The article focuses on the topics: Amine gas treating.read more
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The aza-Michael reaction as an alternative strategy to generate advanced silicon-based (macro)molecules and materials
TL;DR: Aza-Michael reaction can be improved by adding different co-reactants (polar protic solvents, catalysts) and/or adjusting the external energy sources (e.g. moderate to high temperatures or high pressures) as mentioned in this paper.
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Total syntheses of 2,2'-epi-cytoskyrin A, rugulosin, and the alleged structure of rugulin.
TL;DR: The total syntheses of 2,2'-epi-cytoskyrin A, rugulosin, and the alleged structure of rugulin are described, characterized by novel molecular architectures at the core, at which lies a more or less complete, cage-like structural motif termed "skyrane".
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Asymmetric 1,4-Additions to 5-Alkoxy-2(5H)-furanones Enantioselective Synthesis and Absolute Configuration Determination of β-Amino-γ-butyrolactones and Amino Diols
TL;DR: In this article, the synthesis of enantiomerically pure β-amino-δ-butyrolactones via asymmetric conjugate addition of various amines to 5-menthyloxy-2(5H)-furanone is described.
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Base‐induced cycloaddition of N‐(tosylmethyl)imino compounds to michael acceptors: Synthesis of 2,3,4‐trisubstituted pyrroles
H.A. Houwing,A. M. Van Leusen +1 more
TL;DR: A series of N-(tosylmethyl)imino compounds [TosCH2NC(L)A] has been prepared, and applied to a new, base-induced, one-operational synthesis of 2,3,4-trisubstituted pyrroles from electron deficient olefins as discussed by the authors.
Journal ArticleDOI
Antiproliferative activity of aroylacrylic acids. Structure-activity study based on molecular interaction fields
TL;DR: Pharmacophoric pattern of most potent compounds are used as a template for virtual screening, to find similar ones in database of compounds screened against DTP-NCI 60 tumor cell lines, to rationalize the structural characteristics correlated with potency of compounds.