Journal ArticleDOI
Study of the activity of several brain enzymes like markers of the neurotoxicity induced by perinatal exposure to lead and/or cadmium.
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The study of the activity of enzymes is revealed as an effective method to measure the neurotoxic effects produced by the perinatal exposure to lead and/or cadmium.About:
This article is published in Toxicology Letters.The article was published on 2003-08-28. It has received 135 citations till now. The article focuses on the topics: Lead acetate & Neurotoxicity.read more
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Cadmium and Its Neurotoxic Effects
TL;DR: The available finding indicates the neurotoxic effects of Cd that was associated with both biochemical changes of the cell and functional changes of central nervous system, suggesting that neurot toxic effects may play a role in the systemic toxic effects of the exposure to Cd, particularly the long-term exposure.
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Cadmium induces reactive oxygen species generation and lipid peroxidation in cortical neurons in culture.
TL;DR: Data is presented indicating that cadmium induces cellular death in cortical neurons in culture and this death could be mediated by an apoptotic and a necrotic mechanism.
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Heavy metals (Pb, Cd, As and MeHg) as risk factors for cognitive dysfunction: A general review of metal mixture mechanism in brain.
TL;DR: An account of the current knowledge about the individual metal induced cognitive dysfunction mechanisms and common Mode of Actions (MOAs) of quaternary metal mixture (Pb, Cd, As, MeHg) are illustrated to help advancement in mixture toxicology and development of next generation predictive model (such as PBPK/PD) combining both kinetic and dynamic interactions of metals.
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Mini reviewCadmium neurotoxicity
TL;DR: This review accounts for the recent evidence on cadmium mechanisms to induce neurotoxicity, the role of the blood-brain barrier, oxidative stress, interference with calcium, and zinc-dependent processes and apoptosis induction as well as the modulatory effect of metallothionein.
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Effect of lead acetate toxicity on experimental male albino rat
TL;DR: It can be concluded that lead acetate has harmful effect on experimental male albino rats and people are advised to prevent exposure to the lead compound to avoid injurious hazard risk.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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A new and rapid colorimetric determination of acetylcholinesterase activity.
TL;DR: A photometric method for determining acetylcholinesterase activity of tissue extracts, homogenates, cell suspensions, etc., has been described and Kinetic constants determined by this system for erythrocyte eholinesterases are presented.
Book ChapterDOI
Catalase in vitro
TL;DR: In this article, the catalytic activity of catalase has been investigated using ultraviolet (UV) spectrophotometry and Titrimetric methods, which is suitable for comparative studies for large series of measurements.
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Antioxidant effects of α tocopherol, ascorbic acid and l-methionine on lead induced oxidative stress to the liver, kidney and brain in rats
TL;DR: Treatment with antioxidants alone resulted in reversal of oxidative stress without significant decline in tissue lead burden and responses to the treatment with different antioxidants were recorded in the parameters of oxidative damage viz. lipid peroxide level, antioxidant enzymes and thiol contents.
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Antioxidant enzymes responses to cadmium in radish tissues.
TL;DR: The results suggest that in radish, the activity of antioxidant enzymes responds to Cd treatment via the activation of the ascorbate-glutathione cycle for the removal of hydrogen peroxide, or to ensure the availability of glutathione for the synthesis of Cd-binding proteins.