Journal ArticleDOI
Antioxidant effects of α tocopherol, ascorbic acid and l-methionine on lead induced oxidative stress to the liver, kidney and brain in rats
TLDR
Treatment with antioxidants alone resulted in reversal of oxidative stress without significant decline in tissue lead burden and responses to the treatment with different antioxidants were recorded in the parameters of oxidative damage viz. lipid peroxide level, antioxidant enzymes and thiol contents.About:
This article is published in Toxicology.The article was published on 2001-05-11. It has received 447 citations till now. The article focuses on the topics: Ascorbic acid & Lead acetate.read more
Citations
More filters
Journal Article
Heavy metal induced oxidative stress & its possible reversal by chelation therapy.
TL;DR: A comprehensive account of recent developments in the research on heavy metal poisoning particularly the role of oxidative stress/free radicals in the toxic manifestation is attempted, an update about the recent strategies for the treatment with chelating agents and a possible beneficial role of antioxidants supplementation to achieve the optimum effects are attempted.
Journal ArticleDOI
Antioxidant nutrients and lead toxicity.
Ping-Chi Hsu,Yueliang Leon Guo +1 more
TL;DR: Antioxidant nutrients including, vitamin E, vitamin C, vitamin B(6), beta-carotene, zinc, and selenium, are addressed in this review to discuss their beneficial role in lead-induced oxidative stress.
Journal ArticleDOI
Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic.
TL;DR: In this paper, the authors reviewed the mechanistic action of heavy metals according to the available animal and human studies and found similar pathways for these metals to induce toxicity including ROS generation, weakening of the antioxidant defense, enzyme inactivation, and oxidative stress.
Journal Article
Lead toxicity part II: the role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity.
TL;DR: Antioxidants - vitamins B6, C and E, zinc, taurine, N-acetylcysteine, and alpha-lipoic acid - have been studied in lead-exposed animals and the evidence for their use in lead exposure, alone and in conjunction with chelating agents, is reviewed.
Journal ArticleDOI
Oxidative Stress in Lead and Cadmium Toxicity and Its Amelioration
TL;DR: The present review focuses on mechanism of lead- and cadmium-induced oxidate damages and the ameliorative measures to counteract the oxidative damage and pathotoxicity with the use of supplemented antioxidants for their beneficial effects.
References
More filters
Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
TL;DR: Using this method, the liped peroxide level in the liver of rats suffering from carbon tetrachloride intoxication was investigated and was in good agreement with previously reported data obtained by measuring diene content.
Journal ArticleDOI
Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase
TL;DR: The autoxidation of pyrogallol was investigated in the presence of EDTA in the pH range 7.9–10.6, indicating an almost total dependence on the participation of the superoxide anion radical, O2·−, in the reaction.