Journal ArticleDOI
Superoxide Radical: An Endogenous Toxicant
TLDR
The Two Faces of Oxygen Molecular oxygen is both benign and malign and the superoxide dismutases, by catalytically scavenging 0;, provide a defense against it and against any reactive radical species which can be derived from it.Abstract:
The Two Faces of Oxygen Molecular oxygen is both benign and malign On the one hand it provides enormous advantages and on the other it imposes a universal toxicity This toxicity is largely due to the intermediates of oxygen reduction, ie 0;, H202, and OH·, and any organism that avails itself of the benefits of oxygen does so at the cost of maintaining an elaborate system of defenses against these intermediates We will here concern ourselves with the superoxide dismutases which, by catalytically scavenging 0;, provide a defense against it and against any reactive radical species which can be derived from itread more
Citations
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Journal ArticleDOI
Oxygen-derived free radicals in postischemic tissue injury.
TL;DR: It is now clear that oxygen-derived free radicals play an important part in several models of experimentally induced reperfusion injury, and Dysfunction induced by free radicals may be a major component of ischemic diseases of the heart, bowel, liver, kidney, and brain.
Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Journal ArticleDOI
Peroxynitrite oxidation of sulfhydryls. The cytotoxic potential of superoxide and nitric oxide.
TL;DR: Peroxynitrite anion was a less effective thiol-oxidizing agent than its anion, with oxidation presumably mediated by the decomposition products, hydroxyl radical and nitrogen dioxide.
Journal ArticleDOI
Assaying for superoxide dismutase activity: Some large consequences of minor changes in conditions
Wayne F. Beyer,Irwin Fridovich +1 more
TL;DR: The effects of experimental variables on assays based upon the use of either ferricytochrome c or nitro blue tetrazolium are investigated to help investigators to avoid the numerous potential pitfalls which necessarily surround these assay methods.
Journal ArticleDOI
Heme-Containing Oxygenases
References
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Journal ArticleDOI
Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.
Journal ArticleDOI
Superoxide Radical and Superoxide Dismutases
TL;DR: O2- oxidizes the [4Fe-4S] clusters of dehydratases, such as aconitase, causing-inactivation and release of Fe(II), which may then reduce H2O2 to OH- +OH..
Journal ArticleDOI
Superoxide radicals in feline intestinal ischemia
TL;DR: The results of this study indicate that superoxide radicals are primarily responsible for the increased capillary permeability in the ischemic bowel.
Journal ArticleDOI
Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage.
TL;DR: An in vitro model of granulocyte-induced cytotoxicity was constructed utilizing 51Cr-labeled human umbilical vein endothelial cell cultures, suggesting that close approximation of the granulocytes and endothelial cells is necessary for maximal cell injury.