Journal ArticleDOI
Supersensitivity to apomorphine following destruction of the ascending dopamine neurons: quantification using the rotational model.
TLDR
The results contrast with previous reports in which behavioral sensitivity to apomorphine was increased 2- to 7-fold following partial degeneration of central dopamine neurons of following the chronic adminstration of dopamine synthesis inhibitors of receptor blocking agents.About:
This article is published in European Journal of Pharmacology.The article was published on 1977-02-21. It has received 198 citations till now. The article focuses on the topics: Apomorphine & Dopamine.read more
Citations
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The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it
S. Fahn,Gerald Cohen +1 more
TL;DR: The evidence favoring the oxidant stress hypothesis is persuasive, but not yet fully established, and believes that this is the best hypothesis available at present.
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Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system
TL;DR: Fetal rat dopamine-containg neurons were implanted adjacent to the caudate nucleus of adult recipients whose endogenous dopaminergic input had been destroyed to suggest that such implants may be potentially useful in reversing deficits after circumscribed destruction of brain tissue.
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The unilateral 6-hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery and treatments.
TL;DR: The spectrum of behavioral deficits (turning, sensory neglect, etc.), functional recovery and its possible mechanisms, the behavioral effects of widely used pharmacological challenges (amphetamines, apomorphine, selective receptor agonists, L-DOPA), and the effects of treatments which can promote recovery (like neuropeptides, neurotrophins, and grafts are summarized.
Journal ArticleDOI
Collagenase-induced intracerebral hemorrhage in rats.
TL;DR: Collagenase-induced intracerebral hemorrhage is a reproducible animal model for the study of the effects of the hematoma and brain edema in rats and characterized the lesion by histology, brain water content, and behavior.
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Reinnervation of the denervated striatum by substantia nigra transplants: functional consequences as revealed by pharmacological and sensorimotor testing.
Anders Björklund,Stephen B. Dunnett,Stephen B. Dunnett,Ulf Stenevi,M.E. Lewis,M.E. Lewis,Susan D. Iversen,Susan D. Iversen +7 more
TL;DR: It is concluded that SN transplants reinnervation the dorsal part of the neostriatum are able to replace the innate SN in normalizing some aspects of the rats motor behaviour, while their sensorimotor deficits and deficits in consummatory behaviour were unaffected.
References
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Journal ArticleDOI
Fluorescence of Catechol Amines and Related Compounds Condensed With Formaldehyde
TL;DR: In this article, the reaction between formaldehyde and phenylalanine and phenylethylamine derivatives has been studied under mild conditions and it has been shown that the amines primarily condense with formaldehyde to 1,2,3,4-tetrahydroisoquinolines which are involved in a secondary reaction to become highly fluorescent and at the same time insoluble.
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Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system.
TL;DR: The nigrostriatal dopamine system of rats is unilaterally lesioned by intracerebral injection of 6-hydroxy-dopamine which produces an almost complete and selective lesion and the remaining contralateral dopamine system is activated by systemic treatment with amphetamine.
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Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system.
TL;DR: In this article, the effect of L-DOPA and the dopamine receptor stimulating drug apomorphine was studied in rats after unilateral degeneration of the nigrostriatal DA system by intracerebral injection of 6-hydroxydopamine.
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Adipsia and Aphagia after 6-Hydroxydopamine Induced Degeneration of the Nigro-striatal Dopamine System
TL;DR: It was concluded that bilateral complete degeneration of the nigro-striatal DA pathway produces severe, long lasting adipsia and aphagia, hypoactivity, difficulties to initiate activity and loss of exploratory behaviour and curiosity.
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Evidence for dopamine receptor stimulation by apomorphine
TL;DR: Supporting evidence for apomorphine acts on the dopamine receptors whereas amphetamine acts by releasing dopamine is given by further functional, biochemical and histochemical studies.