Journal ArticleDOI
Symptomatic Gastroesophageal Reflux as a Risk Factor for Esophageal Adenocarcinoma
TLDR
There is a strong and probably causal relation between gastroesophageal reflux and esophageaal adenocarcinoma, and the relation between reflux And gastric cardia is relatively weak.Abstract:
Background The causes of adenocarcinomas of the esophagus and gastric cardia are poorly understood. We conducted an epidemiologic investigation of the possible association between gastroesophageal reflux and these tumors. Methods We performed a nationwide, population-based, case–control study in Sweden. Case ascertainment was rapid, and all cases were classified uniformly. Information on the subjects' history of gastroesophageal reflux was collected in personal interviews. The odds ratios were calculated by logistic regression, with multivariate adjustment for potentially confounding variables. Results Of the patients interviewed, the 189 with esophageal adenocarcinoma and the 262 with adenocarcinoma of the cardia constituted 85 percent of the 529 patients in Sweden who were eligible for the study during the period from 1995 through 1997. For comparison, we interviewed 820 control subjects from the general population and 167 patients with esophageal squamous-cell carcinoma. Among persons with recurrent sy...read more
Citations
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Patterns of Cancer Incidence, Mortality, and Prevalence Across Five Continents: Defining Priorities to Reduce Cancer Disparities in Different Geographic Regions of the World
TL;DR: Using the GLOBOCAN and Cancer Incidence in Five Continents databases, overall cancer incidence, mortality, and prevalence, age-adjusted temporal trends, and age-specific incidence patterns in selected geographic regions of the world are described.
Journal ArticleDOI
The Montreal Definition and Classification of Gastroesophageal Reflux Disease: A Global Evidence-Based Consensus
TL;DR: Novel aspects of the new definition include a patient-centered approach that is independent of endoscopic findings, subclassification of the disease into discrete syndrome, and the recognition of laryngitis, cough, asthma, and dental erosions as possible GERD syndromes.
Journal ArticleDOI
Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
Eugenia E. Calle,Rudolf Kaaks +1 more
TL;DR: Gaining a better understanding of the relationship between obesity and cancer can provide new insight into mechanisms of cancer pathogenesis.
Journal ArticleDOI
Updated guidelines 2008 for the diagnosis, surveillance and therapy of Barrett's esophagus.
TL;DR: The guidelines for the diagnosis, surveillance and therapy of Barrett’s esophagus were originally published by the American College of Gastroenterology in 1998 and updated in 2002 and once again reviewed using the National Library of Medicine database.
References
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Statistical methods in cancer research. Vol. 1. The analysis of case-control studies.
N. E. Breslow,N. E. Day +1 more
TL;DR: Case-control studies have come into increasing favour, and they are now one of the commonest forms of epidemiol-ogical studies.
Book
Case-Control Studies: Design, Conduct, Analysis
TL;DR: Case-control studies, often called 'retrospective' studies, provide a research method for investigating factors that may prevent or cause disease.
Journal ArticleDOI
Prevalence and clinical spectrum of gastroesophageal reflux : a population-based study in Olmsted County, Minnesota
TL;DR: Symptoms of reflux are common among white men and women who are 25-74 years of age and heartburn and acid regurgitation are significantly associated with chest pain, dysphagia, dyspepsia, and globus sensation.
Journal ArticleDOI
Increasing incidence of adenocarcinoma of the esophagus and esophagogastric junction
TL;DR: The association with Barrett's esophagus and the parallel increased incidence of cancer in each location is evidence that adenocarcinoma of the Esophageal and of the esophagogastric junction are related disorders.
Journal ArticleDOI
Barrett's esophagus: development of dysplasia and adenocarcinoma.
TL;DR: The results of this study support the need for a long-term clinical, endoscopic, and histologic follow-up program in patients with Barrett's esophagus with an incidence of carcinoma of 1 in 52 patient-years, a 125-fold increase compared with the general Dutch population.