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Pathology and genetics of tumours of the digestive system

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The article was published on 2000-01-01 and is currently open access. It has received 2134 citations till now. The article focuses on the topics: Gastrointestinal pathology.

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Comprehensive molecular characterization of gastric adenocarcinoma

Adam J. Bass, +257 more
- 11 Sep 2014 - 
TL;DR: A comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas (TCGA) project is described and a molecular classification dividing gastric cancer into four subtypes is proposed.
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Retrospective study: The diagnostic accuracy of conventional forceps biopsy of gastric epithelial compared to endoscopic submucosal dissection (STROBE compliant).

TL;DR: According to the analysis, old men plus gastric fundus or antrum of CFB were strongly suggested to perform ESD if precancerous lesions were found and young women with low-grade intraepithelial neoplasia could select regular follow-up.
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International Classification of Childhood Cancer, third edition

TL;DR: The third edition of the International Classification of Diseases for Oncology (ICD‐O‐3), which was published in 2000, introduced major changes in coding and classification of neoplasms, notably for leukemias and lymphomas, which are important groups of cancer types that occur in childhood.
References
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Book

Cancer Incidence in Five Continents

TL;DR: The aim of this study was to establish a database of histological groups and to provide a level of consistency and quality of data that could be applied in the design of future registries.
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p53, the Cellular Gatekeeper for Growth and Division

TL;DR: The author regrets the lack of citations for many important observations mentioned in the text, but their omission is made necessary by restrictions in the preparation of review manuscripts.
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Genetic alterations during colorectal-tumor development.

TL;DR: It is found that ras-gene mutations occurred in 58 percent of adenomas larger than 1 cm and in 47 percent of carcinomas, which are consistent with a model of colorectal tumorigenesis in which the steps required for the development of cancer often involve the mutational activation of an oncogene coupled with the loss of several genes that normally suppress tumors.
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Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma

TL;DR: unique sequences present in more than 90 percent of Kaposi's sarcoma tissues obtained from patients with acquired immunodeficiency syndrome (AIDS) appear to define a new human herpesvirus.
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