Journal ArticleDOI
Synthesis and physicochemical characterization of end-linked poly(ethylene glycol)-co-peptide hydrogels formed by Michael-type addition.
TLDR
The synthesis of novel hybrid hydrogels by stepwise copolymerization of multiarm vinyl sulfone-terminated poly(ethylene glycol) macromers and alpha-omega cysteine oligopeptides via Michael-type additions is described, and structure and properties are very sensitive to the preparation state including stoichiometry and precursor concentration and lesssensitive to the pH during cross-linking.About:
This article is published in Biomacromolecules.The article was published on 2003-02-26. It has received 721 citations till now. The article focuses on the topics: Ethylene glycol & Rheometry.read more
Citations
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Book ChapterDOI
Drug Delivery Systems Based On Mucoadhesive Polymers
TL;DR: This chapter reviews variety of mucoadhesive polymeric systems with a special emphasis on recent developments in the field and describes a new class of covalently interacting muco adhesion polymers termed acrylated mucoADhesive polymers, which are capable of forming covalent link with thiol groups on mucin type glycoproteins, the main component of mucus.
Journal ArticleDOI
Tuning the Mechanical Properties of Multiarm RAFT-Based Block Copolyelectrolyte Hydrogels via Ionic Cross-Linking for 3D Cell Cultures.
Duyen H. T. Nguyen,Robert H. Utama,Kristel C Tjandra,Panthipa Suwannakot,Eric Y. Du,Maria Kavallaris,Richard D. Tilley,J. Justin Gooding +7 more
TL;DR: In this article , the authors combine the best of both systems by developing a synthetic hydrogel with ionic cross-linking of block copolyelectrolytes to rapidly create hydrogels.
Journal ArticleDOI
Azido-functionalized gelatin via direct conversion of lysine amino groups by diazo transfer as a building block for biofunctional hydrogels.
Silke Keller,Tomke Bakker,Benjamin Kimmel,Lisa Rebers,Tobias Götz,Günter E. M. Tovar,Günter E. M. Tovar,Petra J. Kluger,Alexander Southan +8 more
TL;DR: The azido-functional gelatin derivative is found to be a very promising building block for tailoring the bioactivity of materials.
Dissertation
Modification and characterization of poly (ethylene glycol) hydrolytically degradable hydrogels for stem cell delivery
TL;DR: Trabalho realizado na University of Maryland, Baltimore County (UMBC), orienta oportunidades econômica, económico, social, y pedagogical na â’s médicos, diferentes para construir eficientes tecnológicas específicas para proporcionar información acadêmica y Tecnológraica revelada
References
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Journal ArticleDOI
How Matrix Metalloproteinases Regulate Cell Behavior
Mark D. Sternlicht,Zena Werb +1 more
TL;DR: Recent advances shed light on how the structure and function of the MMPs are related and on how their transcription, secretion, activation, inhibition, localization, and clearance are controlled.
Journal ArticleDOI
Cell locomotion and focal adhesions are regulated by substrate flexibility
Robert J. Pelham,Yu-li Wang +1 more
TL;DR: The ability of cells to survey the mechanical properties of their surrounding environment is demonstrated and the possible involvement of both protein tyrosine phosphorylation and myosin-generated cortical forces in this process is suggested.
Journal ArticleDOI
Analysis of Linear Viscoelasticity of a Crosslinking Polymer at the Gel Point
TL;DR: In this paper, a simple memory integral constitutive equation for the stress in crosslinking polymers at their transition from liquid to solid state (gel point) is proposed, which allows for only a single material parameter, the strength S[Pas1/2, and is able to describe every known viscoelastic phenomenon at the gel point.
Journal ArticleDOI
Theory of Molecular Size Distribution and Gel Formation in Branched‐Chain Polymers
TL;DR: The most probable distributions of molecular sizes are calculated for certain types of branched-chain polymers in this paper, which represent an extension of the previous work of Flory, who showed that very large polymeric molecules appear suddenly at a critical extent of reaction, which is predicted to occur very nearly at the experimentally observed gel point.
Journal ArticleDOI
A new derivation of average molecular weights of nonlinear polymers.
TL;DR: A new method for calculating average molecular weights is presented for nonlinear polymers, starting with elementary probability and utilizing the recursive nature of network polymers property relations can be developed more simply.