Journal ArticleDOI
Synthesis and physicochemical characterization of end-linked poly(ethylene glycol)-co-peptide hydrogels formed by Michael-type addition.
TLDR
The synthesis of novel hybrid hydrogels by stepwise copolymerization of multiarm vinyl sulfone-terminated poly(ethylene glycol) macromers and alpha-omega cysteine oligopeptides via Michael-type additions is described, and structure and properties are very sensitive to the preparation state including stoichiometry and precursor concentration and lesssensitive to the pH during cross-linking.About:
This article is published in Biomacromolecules.The article was published on 2003-02-26. It has received 721 citations till now. The article focuses on the topics: Ethylene glycol & Rheometry.read more
Citations
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Controlled growth factor delivery for tissue engineering.
Prakriti Tayalia,David J. Mooney +1 more
TL;DR: An overview of the design criteria for growth factor delivery vehicles with respect to the growth factor itself and the microenvironment for delivery is provided and various methodologies that could be adopted to achieve this localized delivery are discussed.
Journal ArticleDOI
Network formation and degradation behavior of hydrogels formed by Michael-type addition reactions.
TL;DR: A novel theoretical model is presented to describe the formation and hydrolytic degradation of the step-polymerized gels and reveals that structural nonidealities play a key role in determining the degradation behavior of real cross-linked systems.
Journal ArticleDOI
The performance of human mesenchymal stem cells encapsulated in cell-degradable polymer-peptide hydrogels
Sarah B. Anderson,Chien-Chi Lin,Chien-Chi Lin,Donna V. Kuntzler,Kristi S. Anseth,Kristi S. Anseth +5 more
TL;DR: The ability to culture and differentiate hMSCs in MMP-degradable hydrogels polymerized via a thiol-ene reaction scheme is demonstrated and that increased cell-mediated hydrogel degradability facilitates directed differentiation of h MSCs.
Journal ArticleDOI
Engineering the regenerative microenvironment with biomaterials.
Jeffrey J. Rice,Mikaël M. Martino,Laura De Laporte,Federico Tortelli,Priscilla S. Briquez,Jeffrey A. Hubbell +5 more
TL;DR: Important aspects of the healing microenvironment, and how these features can be incorporated within innovative hydrogel scaffolds, are presented.
Journal ArticleDOI
MMP-2 sensitive, VEGF-bearing bioactive hydrogels for promotion of vascular healing
TL;DR: A new class of proteolytically sensitive, biologically active polyethylene glycol (PEG)-peptide hydrogels that can be formed in situ to temporarily protect the arterial injury from blood contact is developed and incorporated endothelial cell-specific biological signals with the goal of enhancing arterial reendothelialization.
References
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Journal ArticleDOI
How Matrix Metalloproteinases Regulate Cell Behavior
Mark D. Sternlicht,Zena Werb +1 more
TL;DR: Recent advances shed light on how the structure and function of the MMPs are related and on how their transcription, secretion, activation, inhibition, localization, and clearance are controlled.
Journal ArticleDOI
Cell locomotion and focal adhesions are regulated by substrate flexibility
Robert J. Pelham,Yu-li Wang +1 more
TL;DR: The ability of cells to survey the mechanical properties of their surrounding environment is demonstrated and the possible involvement of both protein tyrosine phosphorylation and myosin-generated cortical forces in this process is suggested.
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Analysis of Linear Viscoelasticity of a Crosslinking Polymer at the Gel Point
TL;DR: In this paper, a simple memory integral constitutive equation for the stress in crosslinking polymers at their transition from liquid to solid state (gel point) is proposed, which allows for only a single material parameter, the strength S[Pas1/2, and is able to describe every known viscoelastic phenomenon at the gel point.
Journal ArticleDOI
Theory of Molecular Size Distribution and Gel Formation in Branched‐Chain Polymers
TL;DR: The most probable distributions of molecular sizes are calculated for certain types of branched-chain polymers in this paper, which represent an extension of the previous work of Flory, who showed that very large polymeric molecules appear suddenly at a critical extent of reaction, which is predicted to occur very nearly at the experimentally observed gel point.
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A new derivation of average molecular weights of nonlinear polymers.
TL;DR: A new method for calculating average molecular weights is presented for nonlinear polymers, starting with elementary probability and utilizing the recursive nature of network polymers property relations can be developed more simply.