Journal ArticleDOI
Synthesis and physicochemical characterization of end-linked poly(ethylene glycol)-co-peptide hydrogels formed by Michael-type addition.
TLDR
The synthesis of novel hybrid hydrogels by stepwise copolymerization of multiarm vinyl sulfone-terminated poly(ethylene glycol) macromers and alpha-omega cysteine oligopeptides via Michael-type additions is described, and structure and properties are very sensitive to the preparation state including stoichiometry and precursor concentration and lesssensitive to the pH during cross-linking.About:
This article is published in Biomacromolecules.The article was published on 2003-02-26. It has received 721 citations till now. The article focuses on the topics: Ethylene glycol & Rheometry.read more
Citations
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Thiol–Ene Click Chemistry
TL;DR: The radical-mediated thiol-ene reaction has all the desirable features of a click reaction, being highly efficient, simple to execute with no side products and proceeding rapidly to high yield.
Journal ArticleDOI
Hydrogels in regenerative medicine
Brandon V. Slaughter,Shahana S. Khurshid,Omar Z. Fisher,Ali Khademhosseini,Nicholas A. Peppas +4 more
TL;DR: The properties of hydrogels that are important for tissue engineering applications and the inherent material design constraints and challenges are discussed.
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Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering
TL;DR: This review addresses the recent progress in material designs and fabrication approaches leading to the development of bioactive hydrogels as tissue engineering scaffolds as well as exploring different approaches for introducing bioactivity into poly(ethylene glycol) (PEG) hydrogel.
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The Thiol-Michael Addition Click Reaction: A Powerful and Widely Used Tool in Materials Chemistry
Devatha P. Nair,Maciej Podgórski,Maciej Podgórski,Shunsuke Chatani,Tao Gong,Weixian Xi,Christopher R. Fenoli,Christopher N. Bowman +7 more
TL;DR: This review examines the reaction mechanisms, the substrates and catalysts used in the reaction, and the subsequent implementation of the thiol-Michael reaction in materials science.
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25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine
Nasim Annabi,Nasim Annabi,Ali Tamayol,Ali Tamayol,Jorge Alfredo Uquillas,Jorge Alfredo Uquillas,Mohsen Akbari,Mohsen Akbari,Luiz E. Bertassoni,Luiz E. Bertassoni,Chaenyung Cha,Chaenyung Cha,Gulden Camci-Unal,Gulden Camci-Unal,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Nicholas A. Peppas,Ali Khademhosseini,Ali Khademhosseini +18 more
TL;DR: The development of advanced hydrogel with tunable physiochemical properties is highlighted, with particular emphasis on elastomeric, light‐sensitive, composite, and shape‐memory hydrogels, and a number of potential applications and challenges in the utilization in regenerative medicine are reviewed.
References
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How Matrix Metalloproteinases Regulate Cell Behavior
Mark D. Sternlicht,Zena Werb +1 more
TL;DR: Recent advances shed light on how the structure and function of the MMPs are related and on how their transcription, secretion, activation, inhibition, localization, and clearance are controlled.
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Cell locomotion and focal adhesions are regulated by substrate flexibility
Robert J. Pelham,Yu-li Wang +1 more
TL;DR: The ability of cells to survey the mechanical properties of their surrounding environment is demonstrated and the possible involvement of both protein tyrosine phosphorylation and myosin-generated cortical forces in this process is suggested.
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Analysis of Linear Viscoelasticity of a Crosslinking Polymer at the Gel Point
TL;DR: In this paper, a simple memory integral constitutive equation for the stress in crosslinking polymers at their transition from liquid to solid state (gel point) is proposed, which allows for only a single material parameter, the strength S[Pas1/2, and is able to describe every known viscoelastic phenomenon at the gel point.
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Theory of Molecular Size Distribution and Gel Formation in Branched‐Chain Polymers
TL;DR: The most probable distributions of molecular sizes are calculated for certain types of branched-chain polymers in this paper, which represent an extension of the previous work of Flory, who showed that very large polymeric molecules appear suddenly at a critical extent of reaction, which is predicted to occur very nearly at the experimentally observed gel point.
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A new derivation of average molecular weights of nonlinear polymers.
TL;DR: A new method for calculating average molecular weights is presented for nonlinear polymers, starting with elementary probability and utilizing the recursive nature of network polymers property relations can be developed more simply.