Journal ArticleDOI
Synthesis and structure–activity relationship of benzylamine supported platinum(IV) complexes
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TLDR
In this paper, a series of benzylamine derivative (BAD) supported platinum(IV) complexes (PtCl4(BADs)2) have been synthesized and tested in vitro against the MCF-7 cell line, and the 4-fluoro and 4-chloro containing complexes expressed impressive anticancer activities.Abstract:
A series of benzylamine derivative (BAD) supported platinum(IV) complexes (PtCl4(BADs)2) have been synthesized. The complexes were tested in vitro against the MCF-7 cell line, and the 4-fluoro and 4-chloro containing complexes expressed impressive anticancer activities. Their DNA binding nature for a structure–activity relationship (SAR) study was investigated with physicochemical-indicators (PCI) which categorized them as good intercalators for host–guest chemistry. A mechanism for drug efficacy is proposed by analysis of the resultant viscosity and surface tension of PtCl4(BADs)2–DNA solutions named as the drug-friccohesity interaction (DFI). The complexes have shown significant antioxidant activity, determined on the basis of free radical scavenging effects due to their terminating action against the reactive species.read more
Citations
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Preparation and characterization of bionanoemulsions for improving and modulating the antioxidant efficacy of natural phenolic antioxidant curcumin.
TL;DR: The reduced surface tension and increased viscosity of curcumin encapsulated bionanoemulsions within 38.37-52.85mN/m and 0.7947-1.042mPa-s have quantitatively verifiedCurcumin dispersion and interaction within the continuous medium, enabled via thermodynamic shift.
Journal ArticleDOI
Two polypyridyl copper(II) complexes: synthesis, crystal structure and interaction with DNA and serum protein in vitro
TL;DR: Two polypyridyl copper(II) complexes, [Cu(acac)(p-CPIP)(CH3OH)](NO3) (1) and [Cu[acac/(o-NPIP)(NO3)] (2), have been synthesized and characterized by single-crystal analysis, IR and electronic spectroscopy.
Journal ArticleDOI
Physicochemical study of curcumin in oil driven nanoemulsions with surfactants
TL;DR: In this article, a physicochemical profile for 0.220 to 1.099μmol·kg−1 curcumin at Brownian scale, from (298.15 to 308.15) K is reported.
Journal ArticleDOI
Study of curcumin antioxidant activities in robust oil–water nanoemulsions
Parth Malik,Man Singh +1 more
TL;DR: In this paper, the antioxidant activity of curcumin has been investigated in nanoemulsions of peanut, linseed and mustard oils with sodium dodecyl sulphate (SDS), DTAB, tween 20 (Tw-20) and tween-40(Tw-40), respectively.
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Surface tension, viscosity, apparent molal volume, activation viscous flow energy and entropic changes of water + alkali metal phosphates at T = (298.15, 303.15, 308.15) K
Rakesh Kumar Ameta,Man Singh +1 more
TL;DR: In this paper, surface tension and viscosity for water+alkali metals (Li, Na, K) were separately measured over their entire composition range at 29815, 30315 and 30815 K Viscosities and apparent molal volumes were used to calculate activation viscous flow energy and entropy changes.
References
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Journal ArticleDOI
New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening
Philip Skehan,Ritsa Storeng,Dominic A. Scudiero,Anne Monks,James B. McMahon,David T. Vistica,Jonathan T. Warren,Heidi R. Bokesch,Susan Kenney,Michael R. Boyd +9 more
TL;DR: The SRB assay provides a sensitive measure of drug-induced cytotoxicity, is useful in quantitating clonogenicity, and is well suited to high-volume, automated drug screening.
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Structure-antioxidant activity relationships of flavonoids and phenolic acids
TL;DR: The factors underlying the influence of the different classes of polyphenols in enhancing their resistance to oxidation are discussed and support the contention that the partition coefficients of the flavonoids as well as their rates of reaction with the relevant radicals define the antioxidant activities in the lipophilic phase.
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Recognition and reaction of metallointercalators with DNA.
TL;DR: A more complete understanding of how to target DNA sites with specificity will lead not only to novel chemotherapeutics but also to a greatly expanded ability for chemists to probe DNA and to develop highly sensitive diagnostic agents.
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Tris(phenanthroline)ruthenium(II) enantiomer interactions with DNA: Mode and specificity of binding
TL;DR: The results of these studies indicated that both isomers bind to DNA by a single mode, but the two isomers differ, however, in their effect on the hydrodynamic properties of DNA as measured by viscosity and, therefore, probably differ in their individual binding modes.
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Adducts of the antitumor drug cis-diamminedichloroplatinum(II) with DNA: formation, identification, and quantitation
Anne Marie J. Fichtinger-Schepman,J. L. Van Der Veer,J. H. J. Den Hartog,P. H. M. Lohman,Jan Reedijk +4 more
TL;DR: In kinetic studies on the formation of the various adducts, a clear preference of the Pt compound to react with guanines occurring in the base sequence d(pGpG) was established and the method was used to optimize the digestion conditions for cis-DDP-treated DNA.