Synthesis of new strands of mitochondrial and nuclear deoxyribonucleic acid by semiconservative replication.
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The result suggests that replication of mitochondrial DNA is by a semiconservative mechanism and that there is little, if any, repair of the DNA.About:
This article is published in Journal of Biological Chemistry.The article was published on 1969-03-25 and is currently open access. It has received 49 citations till now. The article focuses on the topics: Semiconservative replication & DNA replication.read more
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Progress in Molecular and Subcellular Biology
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TL;DR: This review attempts to present a unified view of the current understanding of the process of DNA repair in mitochondria with an emphasis on issues that appear controversial.
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Apparent Turnover of Mitochondrial Deoxyribonucleic Acid and Mitochondrial Phospholipids in the Tissues of the Rat
TL;DR: The apparent turnovers of mitochondrial DNA and of the phospholipids, cardiolipin, lecithin, and phosphatidyl ethanolamine, have been determined simultaneously in the mitochondria of rat liver, kidney, brain, and heart.
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Is there more to aging than mitochondrial DNA and reactive oxygen species
TL;DR: This review critically analyzes the experimental evidence that supports and refutes the Free Radical/Mitochondrial Theory of Aging, which has dominated the field of aging research for almost half a century.
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Maternal inheritance of the mouse mitochondrial genome is not mediated by a loss or gross alteration of the paternal mitochondrial DNA or by methylation of the oocyte mitochondrial DNA
TL;DR: The mitochondrial DNA is not differentially methylated during spermatogenesis, and no methylation differences were detected in mitochondrial DNA from sperm and oocytes following digestion with seven methylation-sensitive restriction enzymes.
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Journal ArticleDOI
Apparent Turnover of Mitochondrial Deoxyribonucleic Acid and Mitochondrial Phospholipids in the Tissues of the Rat
TL;DR: The apparent turnovers of mitochondrial DNA and of the phospholipids, cardiolipin, lecithin, and phosphatidyl ethanolamine, have been determined simultaneously in the mitochondria of rat liver, kidney, brain, and heart.
Journal ArticleDOI
Circular mitochondrial DNA
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Ultracentrifuge and electron microscope studies on the structure of mitochondrial DNA.
TL;DR: The structure of mitochondrial DNA from oocytes of Xenopus laevis and Rana pipiens has been studied by band centrifugation and electron microscopy to provide calibrations for S versus molecular weight for circular forms of DNA.
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Biosynthesis of DNA by Isolated Mitochondria: Incorporation of Thymidine Triphosphate-2-C 14
Peter Parsons,Melvin V. Simpson +1 more
TL;DR: Thymidine triphosphate-2-C14 and other deoxynucleoside Triphosphates are incorporated into the DNA of isolated mitochondria from rat liver cells and have the properties of mitochondrial rather than nuclear DNA, and end-group studies indicate labeling of the interior of the molecule.
Related Papers (5)
Mitochondrial DNA: physicochemical properties, replication, and genetic function.
Piet Borst,A.M. Kroon +1 more