Journal ArticleDOI
Systematic review: adherence issues in the treatment of ulcerative colitis
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TLDR
First‐line therapy for ulcerative colitis is 5‐aminosalicylic acid, which suffers from poor patient adherence outside the clinical trial setting.Abstract:
Ulcerative colitis is a chronic inflammatory and debilitating disease requiring lifelong treatment. First-line therapy for ulcerative colitis is 5-aminosalicylic acid, which suffers from poor patient adherence outside the clinical trial setting. Formulations to deliver 5-aminosalicylic acid to the disease activity site, both orally and topically, are often inconvenient and require multiple daily dosing. Such regimens can interfere with normal life and reduce the overall quality of life, negatively impacting on treatment adherence and leading to poorer long-term outcomes. These include increased morbidity with an elevated risk of symptomatic relapse, possible greater risk of colorectal cancer and higher overall costs of care. Ulcerative colitis patients cite treatment regimen complexity, tablet quantity and dose frequency as key negative influencers of adherence. Solutions to these issues include addressing patient concerns, simplifying daily regimens and utilizing new formulations such as micropellet and multimatrix oral formulations, rectal gel and once-daily suppository formulations. This review examines the prevalence and impact of non-adherence to 5-aminosalicylic acid therapy among patients with ulcerative colitis, as well as drug delivery strategies that may enhance dosing regimens to improve patient acceptability, adherence and long-term clinical outcomes. It is a combination of understanding patient behaviour, recognizing signs of non-adherent behaviour and utilizing management strategies to change behaviour that will improve patient outcomes.read more
Citations
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Journal ArticleDOI
ACG Clinical Guideline: Ulcerative Colitis in Adults
TL;DR: These guidelines indicate the preferred approach to the management of adults with UC and represent the official practice recommendations of the American College of Gastroenterology.
Journal ArticleDOI
The impact of medication regimen factors on adherence to chronic treatment: a review of literature
Karen S. Ingersoll,Jessye Cohen +1 more
TL;DR: A suggestive pattern of the importance of regimen factors, specifically dose frequency and regimen complexity, emerged from this review, despite most studies failed to use state-of-the-art methods of measuring adherence.
Journal ArticleDOI
Oral 5-aminosalicylic acid for induction of remission in ulcerative colitis
TL;DR: 5-ASA was significantly superior to placebo with regard to all measured outcome variables and the failure to induce global/clinical remission, global/ clinical improvement, endoscopic remission, adherence, adverse events, withdrawals due to adverse events and withdrawals or exclusions after entry were found.
Journal ArticleDOI
Oral 5‐aminosalicylic acid for maintenance of remission in ulcerative colitis
TL;DR: The existing review of oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis is updated and includes more recent studies and evaluates the effectiveness, dose-responsiveness, and safety of 5-ASA preparations in terms of more precise outcome measures.
Journal ArticleDOI
Factors Associated With Non-Adherence to Oral Medication for Inflammatory Bowel Disease: A Systematic Review
TL;DR: This is the largest review of factors associated with non-adherence in IBD and calls into question some of the conclusions of earlier reviews that did not take into account nonsignificant findings.
References
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Journal ArticleDOI
Adherence to long-term therapies: evidence for action.
TL;DR: This report highlights the need for a multi-disciplinary approach to adherence, emphasizes system factors that need to be addressed in successfully implementing adherence-enhancing strategies, and provides illustrative examples of the ways in which professionals have contributed in their own fields of expertise including cardiovascular care among other fields.
Journal ArticleDOI
Patient Adherence and Medical Treatment Outcomes: A Meta-Analysis
TL;DR: According to a stringent random effects model, adherence is most strongly related to outcomes in studies of nonmedication regimens, where measures of adherence are continuous, and where the disease is chronic (particularly hypertension, hypercholesterolemia, intestinal disease, and sleep apnea).
Journal ArticleDOI
A Systematic Review of Adherence With Medications for Diabetes
TL;DR: It is confirmed that many patients for whom diabetes medication was prescribed were poor compliers with treatment, including both OHAs and insulin, however, electronic monitoring systems were useful in improving adherence for individual patients.
Journal ArticleDOI
A Systematic Review of Adherence With Medications for Diabetes: Response to Wens et al.
TL;DR: It is confirmed that many patients for whom diabetes medication was prescribed were poor compliers with treatment, including both OHAs and insulin, however, electronic monitoring systems were useful in improving adherence for individual patients.
Journal ArticleDOI
Systematic review of randomised trials of interventions to assist patients to follow prescriptions for medications
TL;DR: In this paper, the results of randomised controlled trials (RCTs) of interventions to help patients follow prescriptions for medications were summarised, and the most effective interventions did not lead to substantial improvements in adherence.
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