Journal ArticleDOI
Tailoring the degradation of hydrogels formed from multivinyl poly(ethylene glycol) and poly(vinyl alcohol) macromers for cartilage tissue engineering.
TLDR
In this paper, degradable hydrogels were used to tune the degradation profiles of polymer cell carriers to match cell and tissue growth, which is an important design parameter for (cartilage) tissue engineering.About:
This article is published in Biomacromolecules.The article was published on 2003-01-23. It has received 286 citations till now. The article focuses on the topics: Self-healing hydrogels & Vinyl alcohol.read more
Citations
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Hydrogels in Biology and Medicine: From Molecular Principles to Bionanotechnology†
TL;DR: This work highlights recent developments in engineering uncrosslinked and crosslinked hydrophilic polymers for biomedical and biological applications and shows how such systems' intelligent behavior can be used in sensors, microarrays, and imaging.
Journal ArticleDOI
Hydrogels in regenerative medicine
Brandon V. Slaughter,Shahana S. Khurshid,Omar Z. Fisher,Ali Khademhosseini,Nicholas A. Peppas +4 more
TL;DR: The properties of hydrogels that are important for tissue engineering applications and the inherent material design constraints and challenges are discussed.
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The development of microgels/nanogels for drug delivery applications
TL;DR: This review describes the recent developments of microgel/nanogel particles as drug delivery carriers for biological and biomedical applications, including stability for prolonged circulation in the blood stream, novel functionality for further bioconjugation, and biodegradability for sustained release of drugs for a desired period of time.
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BIOMATERIALS: Where We Have Been and Where We Are Going
TL;DR: This new generation of biomaterials includes surface modification of materials to overcome nonspecific protein adsorption in vivo, precision immobilization of signaling groups on surfaces, and design of sophisticated three-dimensional architectures to produce well-defined patterns for diagnostics.
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Cell Encapsulation in Biodegradable Hydrogels for Tissue Engineering Applications
TL;DR: Important considerations for designing biodegradable hydrogels for cell encapsulation are described and recent advances in material design and their applications in tissue engineering are highlighted.
References
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Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-poly(.alpha.-hydroxy acid) diacrylate macromers
TL;DR: The amphiphilic nature of the macromers causes them to assume a micellar conformation, which enables them to undergo rapid photopolymerization, resulting in the formation of crosslinked gels.
Journal ArticleDOI
Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels.
Robert L. Mauck,Michael A. Soltz,Christopher C.-B. Wang,Dennis D. Wong,Pen-Hsiu Grace Chao,Wilmot B. Valhmu,Clark T. Hung,Gerard A. Ateshian +7 more
TL;DR: The hypothesis that the application of dynamic deformational loading at physiological strain levels enhances chondrocyte matrix elaboration in cell-seeded agarose scaffolds to produce a more functional engineered tissue construct than in free swelling controls is tested.
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Variations in the intrinsic mechanical properties of human articular cartilage with age, degeneration, and water content.
Cecil Armstrong,Van C. Mow +1 more
TL;DR: The visual or histological appearance of a cartilage specimen may be a poor indicator of its ability to function as the bearing material in the intact joint and a more reliable indicator of the functional properties of a specimen can be obtained by direct mechanical testing or by biochemical analysis of its composition.
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Cytocompatibility of UV and visible light photoinitiating systems on cultured NIH/3T3 fibroblasts in vitro
TL;DR: The results demonstrated that at low photoinitiator concentrations, all of the initiator molecules were cytocompatible with the exception of CQ, Irgacure 651, and 4EDMAB which had a relative survival ~ 50% lower than a control.
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Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue-engineered cartilage.
Gordana Vunjak-Novakovic,Ivan Martin,Bojana Obradovic,Steven Treppo,Alan J. Grodzinsky,Robert Langer,Lisa E. Freed +6 more
TL;DR: It is suggested that the hydrodynamic conditions in tissue‐culture bioreactors can modulate the composition, morphology, mechanical properties, and electromechanical function of engineered cartilage.