Targeting cancer chemotherapeutic agents by use of lipiodol contrast medium
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TLDR
The results suggest that targeting of the anti‐cancer agent to the tumor is important for treatment of solid malignant tumors.Abstract:
Arterially administered Lipiodol Ultrafluid contrast medium selectively remained in various malignant solid tumors because of the difference in time required for the removal of Lipiodol contrast medium from normal capillaries and tumor neovasculature. Although blood flow was maintained in the tumor, even immediately after injection Lipiodol contrast medium remained in the neovasculature of the tumor. To target anti-cancer agents to tumors by using Lipiodol contrast medium as a carrier, the characteristics of the agents were examined. Anti-cancer agents had to be soluble in Lipiodol, be stable in it, and separate gradually from it so that the anti-cancer agents would selectively remain in the tumor. These conditions were found to be necessary on the basis of the measurement of radioactivity in VX2 tumors implanted in the liver of 16 rabbits that received arterial injections of 14C-labeled doxorubicin. Antitumor activities and side effects of arterial injections of two types of anti-cancer agents were compared in 76 rabbits with VX2 tumors. Oily anti-cancer agents that had characteristics essential for targeting were compared with simple mixtures of anti-cancer agents with Lipiodol contrast medium that did not have these essential characteristics. Groups of rabbits that received oily anti-cancer agents responded significantly better than groups that received simple mixtures, and side effects were observed more frequently in the groups that received the simple mixtures. These results suggest that targeting of the anti-cancer agent to the tumor is important for treatment of solid malignant tumors.read more
Citations
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Chemoembolization of hepatocellular carcinoma.
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Journal Article
Use of oily contrast medium for selective drug targeting to tumor: enhanced therapeutic effect and X-ray image
TL;DR: Highly malignant rabbit tumor (VX-2) was implanted at the periphery of the liver in 63 rabbits and the biological activity of SMANCS was determined and was found to be significant in both tumor and liver even 7 days after injection.
Journal ArticleDOI
Selective targeting of anti-cancer drug and simultaneous image enhancement in solid tumors by arterially administered lipid contrast medium
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TL;DR: Twenty‐four patients with various solid tumors including metastatic liver cancer and cancer of the lung, gallbladder, and pancreas were treated with a lipophilic macromolecular drug, copoly(styrene‐maleic acid) conjugated neocarzinostatin (SMANCS), finding a pronounced and long‐lasting anti‐cancer effect.
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