Showing papers in "European Journal of Cancer and Clinical Oncology in 1983"

TL;DR: Differences in ranking of severity of side-effects were evident when patient groups were divided by sex, age, marital status and domestic situation, as well as by diagnosis, treatment and response.

TL;DR: A clinical evaluation of arterial infusion of high-molecular-weight antitumor agent SMANCS dissolved in lipid lymphographic agent (thiodol) in 44 patients with mostly unresectable hepatoma demonstrated significant merits both therapeutically and diagnostically.

TL;DR: In this article, the authors showed that tamoxifen-induced growth inhibition is associated with major changes in the cell cycle kinetic parameters of MCF 7 cells, indicating that this drug is a cell cycle phase-specific growth inhibitory agent.

TL;DR: It is concluded that a single-item linear analogue self-assessment asking the direct question "How would you rate your quality of life today?" is a valid and reliable indicator of the quality oflife of patients with cancer.

TL;DR: Among patients with ovarian cancer, there was a significant association between performance status and LASA scores for general well-being, breathlessness and physical activity, and among patients with SCBC and melanoma, high correlations were observed.

TL;DR: A significant advance in targeted chemotherapy in that 77% of the animals in the magnetically localized doxorubicin microsphere treatment groups exhibited total remission after only one regimen of drug therapy.

TL;DR: Two human brain tumors which were previously established in nude mice were used to determine antitumor efficacy of various therapeutic agents and a new drug being investigated by the NCI was found to be very effective against the U-251 tumor.

TL;DR: Vascular occlusion has been tested as a means of inducing regrowth delay, local control, reduced cell viability and prolonged alteration of blood flow in mouse tumours, with the magnitude of the response being proportional to the duration of clamping.

TL;DR: It is concluded that, compared with the single high-dose regimen, the daily low dose for 5 days is preferable in cases where the patient might be cured by a regimen including CDDP.

TL;DR: In 585 cases with primary cutaneous stage I malignant melanoma prognostic parameters were examined, the most effective proved to be tumor thickness and mitotic activity, particularly when combined as a prognostic index.

TL;DR: It was concluded that the cytosols from human intracranial meningiomas contain progesterone receptors in the absence of oestrogen receptors, which may indicate that (anti)-progestational treatment could be of potential value in cases which cannot be treated by surgery alone.

TL;DR: There is now appreciable evidence for direct oestrogenic stimulation of cell proliferation in both normal and neoplastic tissues, as well as detailed studies employing model systems employing these model systems, which greatly enhanced understanding of the hormonal control of tumour growth.

TL;DR: The membrane antigens of fifteen colorectal tumours were studied using a number of monoclonal antibodies and the immunoperoxidase technique on frozen sections to demonstrate differences in the membrane structure of the cancer cells within the tumour mass of given patients and also readily demonstrate differences between tumours that were indistinguishable by histological and other standard criteria.

TL;DR: The membrane transport of cytosine arabinoside (araC) has been studied in blasts freshly isolated from a variety of acute leukaemias and larger transport of araC may explain the greater sensitivity of acute myeloid leukaemia to this drug.

TL;DR: The use of common reagents and methodologies diminished the inter-laboratory variation coefficients of the protein assay to 14-17%; however, the protein estimation still needs to be improved.

TL;DR: The rapid extravasation and cellular uptake of magnetically focused microsphere explains the extremely rapid tumoricidal effect previously observed when doxorubicin-containing microspheres were targeted to the tumor.

TL;DR: It is suggested that treatment with some inducers should be effective for inducing most acute myeloid leukemia cells to differentiate into morphologically and functionally mature granulocytes and macrophages.

TL;DR: There is no advantage therapeutically in combining vincristine and adriamycin in patients with advanced breast cancer, and the subjective and haematological toxicity was similar in both groups.

TL;DR: It is concluded that this drug is active in stomach cancer and that it warrants further trials in combination chemotherapy.

TL;DR: The data suggested that these 5 xenograft lines may be divided into 2 groups, and Hypoxanthine and HPP, alone or in combination, caused a rapid depletion of PRPP in each tumor line examined, and this may be responsible for the decreased formation of FUra ribonucleotides observed.

TL;DR: The platelet functional tests investigated were of little help for predicting these clinical complications and the possible role played by platelet number and function was not established.

TL;DR: A highly significant correlation between ploidy and proliferative activity was observed, with near-diploid and diploid tumours being associated with a low S phase fraction, suggesting that multiploidy might be a phenomenon associated with the menopause.

TL;DR: Aminoglutethimide is an effective endocrine therapy in advanced postmenopausal breast cancer, particularly for bone deposits, and disease stabilization is associated with symptomatic and survival benefit similar to CR-PR.

TL;DR: Massive chemotherapy could be the best treatment for NHML in relapse, but the high percentage of early therapy-related deaths is a strong limiting factor for patients before relapse.

TL;DR: It is suggested that steroid receptors significantly affect survival but not DFI, and analysis of both grade and ER content may give a more accurate indication of prognosis in operable breast cancer.

TL;DR: Whole-body hyperthermia at 42 degrees C can be effective but the potential toxicity limits its use to those patients with severe complaints for whom no other palliative treatment is available.

TL;DR: Patients with advanced soft tissue sarcoma who had received no prior chemotherapy entered a randomised phase II study comparing carminomycin with adriamycin, finding CMM showed significantly lower antitumour activity and patients on ADM had only a marginally significant longer duration of survival than the patients receiving CMM.

TL;DR: Post-mortem data suggest that miconazole or ketoconazole might reduce the incidence of disseminated candidiases in neutropenic patients.

TL;DR: A classification of low-, medium- and high-risk malignant melanoma may prove helpful in the selection of different therapeutical modalities for individual patients and in evaluating their efficacy.