Open AccessJournal Article
Terminal chromosome attachments.
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TLDR
Four cases of attachment of chromosome material at the ends of normal chromosomes in Drosophila are presented to serve as a parallel to cases of apparent terminal breakage and reunion in certain rearrangements in man.Abstract:
Descriptions are presented of four cases of attachment of chromosome material at the ends of normal chromosomes in Drosophila. Since no material appears to be missing from the polytene chromosomes and there are no ill effects to the organism in morphology, viability, or fertility when the chromosome is made homozygous, it is argued that the attachment occurred without the loss of any essential genetic material and that, in all probability, the break at the end of the chromosome occurred within the telomere of the chromosome. These cases may serve as a parallel to cases of apparent terminal breakage and reunion in certain rearrangements in man.read more
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Journal ArticleDOI
Polytene chromosomes, heterochromatin, and position effect variegation.
TL;DR: The chapter presents the studies on the morphological and morphofunctional organization of chromosome fragments in close proximity to heterochromatin demonstrated that genetic inactivation is related to compaction of the chromosome region and to the acquisition of the properties of a heterochromaatin.
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Genetic basis of differences in genital morphology among three sibling species of drosophila.
TL;DR: The classical neo-Darwinian view maintains that the genetic basis of phenotypic differences among populations and individuals within a species is similar to that among species.
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Nonreciprocal and jumping translocations of 15q1----qter in Prader-Willi syndrome.
TL;DR: Findings in the present series were normal parental age in the de novo 45-chromosome cases, an apparently random distribution of telomeric breakpoints, and the occurrence of different breakpoints within the 15q1 region.
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The entire compound autosomes of drosophila melanogaster
E. Novitski,D. Grace,C. Strommen +2 more
TL;DR: Three new unusual compound chromosomes have been synthesized in Drosophila melanogaster and are recovered in progeny with frequencies lower than expectation partly because of zygote mortality associated with these chromosomes, and partlyBecause of a failure of spermiogenesis.
Journal ArticleDOI
Telomeric fusion in pre-T-cell acute lymphoblastic leukemia
Rodman Morgan,V. Jarzabek,J. P. Jaffe,Barbara Kaiser Hecht,Frederick Hecht,Avery A. Sandberg +5 more
TL;DR: The findings in this case suggest that telomeric fusion may function as a mechanism for the development of chromosome rearrangements that may play a role, albeit rarely, in human neoplasia.