Journal ArticleDOI
The 1968-1969 cholera-vaccine field trial in rural east pakistan. Effectiveness of monovalent ogawa and inaba vaccines and a purified inaba antigen, with comparative results of serological and animal protection tests
Wiley H. Mosley,Woodward We,K. M. A. Aziz,Rahman As,Chowdhury Ak,Ansaruddin Ahmed,J.C. Feeley +6 more
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This article is published in The Journal of Infectious Diseases.The article was published on 1970-05-01. It has received 77 citations till now. The article focuses on the topics: Cholera vaccine.read more
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Journal ArticleDOI
Perspective: Hypothesis: Serum IgG Antibody Is Sufficient to Confer Protection against Infectious Diseases by Inactivating the Inoculum
TL;DR: "Herd" immunity conferred by vaccines on viral and bacterial diseases is best explained by serum antibodies that inactivate the inoculum on mucosal surfaces, thus reducing the pathogen's transmission.
Journal ArticleDOI
Response of man to infection with Vibrio cholerae. I. Clinical, serologic, and bacteriologic responses to a known inoculum.
Richard A. Cash,S. I. Music,Joseph P. Libonati,Merrill J. Snyder,Richard P. Wenzel,Richard B. Hornick +5 more
TL;DR: The spectrum of illness and the immunologic response produced by cholera in volunteers were studied and Titers of vibriocidal antibody rose after diarrhea, peaked the second week after challenge, and rapidly fell during the next four weeks.
Journal ArticleDOI
Immunology of gut mucosal vaccines
TL;DR: In this article, a review of the immune responses elicited in humans by enteric vaccines is presented, focusing on the cross-talk between mucosal and systemic immunity, and identifying an immunological correlate of protection in the course of field trials of efficacy, animal models or human challenge studies.
Journal ArticleDOI
Hypothesis for Vaccine Development: Protective Immunity to Enteric Diseases Caused by Nontyphoidal Salmonellae and Shigellae May Be Conferred by Serum IgG Antibodies to the O-Specific Polysaccharide of Their Lipopolysaccharides
TL;DR: In this paper, the authors proposed that serum IgG antibodies to the O-specific polysaccharide (O-SP) of their lipopolysaccharides (LPSs) will confer protective immunity to these two pathogens.
Journal ArticleDOI
Response of Man to Infection with Vibrio cholerae. II. Protection from Illness Afforded by Previous Disease and Vaccine
Richard A. Cash,Richard A. Cash,S. I. Music,S. I. Music,S. I. Music,J. P. Libonati,J. P. Libonati,John P. Craig,John P. Craig,Nathaniel F. Pierce,R. B. Hornick,R. B. Hornick +11 more
TL;DR: In this article, the authors evaluated human immunity acquired after cholera or provided by choline vaccines and found that immunity, either naturally acquired or vaccine-induced, appeared to be directed against the vibrio rather than against the toxin.
Related Papers (5)
The antigens of Vibrio cholerae involved in the vibriocidal action of antibody and complement.
Sim Hee Neoh,Derrick Rowley +1 more