Journal ArticleDOI
The binding of dihematoporphyrin ether (photofrin II) to human serum albumin.
TLDR
The kinetics of quenching of tryptophan fluorescence in HSA by PII indicates that there is one main porphyrin-binding site affecting this fluorescence, which seems to have a slightly higher affinity for PII than the remaining sites.About:
This article is published in Clinica Chimica Acta.The article was published on 1985-02-15. It has received 50 citations till now. The article focuses on the topics: Human serum albumin & Serum albumin.read more
Citations
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Journal ArticleDOI
Photosensitizers: therapy and detection of malignant tumors
TL;DR: Perhaps the most significant advance during the past year has been the initiation of Phase III clinical trials of PDT vs standard therapy in treatment of superficial bladder cancer and obstructive endobronchial tumors.
Journal ArticleDOI
Porphyrin photosensitization and phototherapy
TL;DR: The literature in the field of porphyrin photosensitization has been growing with an increasing rate since the last yearly review on the topic was published in this journal, and this field will receive significant attention in the present review.
Journal ArticleDOI
Characterization of Photofrin photobleaching for singlet oxygen dose estimation during photodynamic therapy of MLL cells in vitro.
TL;DR: In vitro experiments performed in which MatLyLu cells were incubated in Photofrin and then irradiated with 532 nm light, and the generation of fluorescent photoproducts was not a result of singlet oxygen reactions exclusively, and therefore did not yield additional information to aid in quantifying singletoxy dose.
Journal ArticleDOI
Role of high-, low- and very low-density lipoproteins in the transport and tumor-delivery of hematoporphyrin in vivo.
TL;DR: In vitro-prepared complexes of hematoporphyrin with lipoprotein fractions isolated from mouse serum have been injected intracardiacally into mice affected by MS-2 fibrosarcoma.
Journal Article
Uptake of hematoporphyrin derivative by normal and malignant cells: effect of serum, pH, temperature, and cell size.
Ralph M. Böhmer,George Morstyn +1 more
TL;DR: The data suggest that acidic pH, differences in extracellular serum concentrations of malignant tumor tissue, as well as the increased size of tumor cells, may play an important role in the selective uptake of HPD by malignant tumors.
References
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Journal Article
Photoradiation therapy for the treatment of malignant tumors
Thomas J. Dougherty,Jerome E. Kaufman,Abraham Goldfarb,Kenneth R. Weishaupt,Donn Boyle,Arnold Mittleman +5 more
TL;DR: Deep-seated and pigmented tumors required a higher dose of drug for effective treatment than did the more superficial and nonpigmented lesions, and a high therapeutic ratio between tumor and skin response has been obtained.
Journal ArticleDOI
The use of a derivative of hematoporphyrin in tumor detection.
Journal ArticleDOI
Properties of graphical representations of multiple classes of binding sites.
Book
Excited states of proteins and nucleic acids
Robert F. Steiner,Ira Weinryb +1 more
TL;DR: The Luminescence of Organic Molecules and the Effect of Nuclear Displacements on the Emission Spectrum and Lifetime is studied.
Book ChapterDOI
The structure of the active component of hematoporphyrin derivative.
TL;DR: Photoradiation therapy for local treatment of malignant tumors utilizing hematoporphyrin derivative as photosensitizing drug is undergoing clinical trials in several centers in the U. S. and abroad.