Journal ArticleDOI
The Claisen Rearrangement. Response to Solvents and Substituents: The Case for Both Hydrophobic and Hydrogen Bond Acceleration in Water and for a Variable Transition State
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This article is published in Accounts of Chemical Research.The article was published on 1997-05-13. It has received 147 citations till now. The article focuses on the topics: Claisen rearrangement & Hydrogen bond.read more
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Click Chemistry: Diverse Chemical Function from a Few Good Reactions.
TL;DR: In this paper, a set of powerful, highly reliable, and selective reactions for the rapid synthesis of useful new compounds and combinatorial libraries through heteroatom links (C-X-C), an approach called click chemistry is defined, enabled, and constrained by a handful of nearly perfect "springloaded" reactions.
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Organic Reactions in Aqueous Media with a Focus on Carbon−Carbon Bond Formations: A Decade Update
TL;DR: Reaction of R,â-Unsaturated Carbonyl Compounds 3127: Reaction of R-UnSaturated Carbonies 3127 7.1.6.
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“On Water”: Unique Reactivity of Organic Compounds in Aqueous Suspension
TL;DR: This workFloat their problematic reactions on water and to send observations of success or failure to us at onwater@scripps.edu for public dissemination with attribution.
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Click-Chemie: diverse chemische Funktionalität mit einer Handvoll guter Reaktionen
TL;DR: In this paper, the authors show how in der Natur am haufigsten vorkommenden Verbindungen, so fallt auf, dass the Bildung von Kohlenstoff-Heteroatom-Bindungen gegenuber der von KHO-Kohlenstoffs-KHO-Bindingsen deutlich bevorzugt is, and das Medium naturlicher Reaktionen zumeist Wasser ist.
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Theory of Solutions of Molecules Containing Widely Separated Charges with Special Application to Zwitterions
TL;DR: In this paper, the electrical contribution to the chemical potential of an ion having an arbitrary charge distribution is calculated with the aid of the Debye-Huckel theory, and the calculation is based upon a general solution in polar coordinates of the approximate Debye Huckel equation, Δψ-κ2ψ=0.
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Hydrophobic acceleration of Diels-Alder reactions
Darryl Rideout,Ronald Breslow +1 more
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Theoretical relations among rate constants, barriers, and Broensted slopes of chemical reactions
TL;DR: In this paper, a simple relation, ΔF* = (λ(1 + Δ/λ)^2)/4, was explored in a slightly modified version for reactions with considerable resonance splitting, such as atom transfers, proton transfers, and strong-overlap electron transfers.