The distribution of dust mite allergen in the houses of patients with asthma.
Reads0
Chats0
TLDR
The results suggested that natural exposure to this dust allergen allows occasional fecal particles to enter the lungs and that these particles contain very concentrated allerGEN.Abstract:
Using an inhibition radioimmunoassay for the major allergen from Dermatophagoides pteronyssinus (antigen P1), we studied the distribution of this dust allergen in the houses of patients with asthma. Both bed and floor dust samples contained a wide range of antigen P1, 100 to 100,000 ng/g of fine dust, and this concentration correlated well with the number of mite bodies (r = 0.81, p less than 0.001). We were unable to detect antigen P1 in the air of undisturbed rooms. However, during domestic activity, between 1 and 30 ng were collected on a filter than sampled air for 45 min at 17 L/min. Using a cascade impactor it was shown that greater than 80% of the airborne antigen P1 was associated with particles greater than 10 mu in diameter. Some of the particles containing allergen could be identified because they formed precipitin rings when impacted onto agarose containing rabbit antimite antiserum. These particles had the physical appearance of mite feces, which are the major source of antigen P1 in mite cultures. The results suggested that natural exposure to this dust allergen allows occasional fecal particles to enter the lungs and that these particles contain very concentrated allergen.read more
Citations
More filters
Journal ArticleDOI
Asthma and domestic air quality
TL;DR: It is concluded that indoor air pollution may be an important risk for asthma and the health impacts of building design and management require greater recognition and further research.
Journal ArticleDOI
Increase in skin mast cells following chronic house dust mite exposure.
TL;DR: Application of inhalant allergens in high concentration to the mildly abraded skin of sensitive patients with atopic dermatitis gave rise to eczematous skin responses at 48 h, and repeated application of allergen induced an increase in skin mast cells by 6 days, the mast cell hyperplasia replacing the earlier basophil infiltration.
Journal ArticleDOI
Effective education of adults with asthma who are allergic to dust mites
Karen Huss,Edward N. Squire,Gary B. Carpenter,Laurie J. Smith,Richard W. Huss,Kalman Salata,Maria Paola Salerno,Damien Agostinelli,Joyce Hershey +8 more
TL;DR: Adherence, number of observed and self-reported mite-avoidance measures implemented after visit, was higher for the computer group, and the computer-instructed group was significantly less symptomatic by study weeks 9 and 10.
Journal ArticleDOI
Airborne cat (Fel d I), dog (Can f I), and mite (Der I and Der II) allergen levels in the homes of Japan
Masahiro Sakaguchi,Sakae Inouye,Tatehisa Irie,Hiroshi Miyazawa,Mika Watanabe,Hiroshi Yasueda,Takao Shida,Hiroshi Nitta,Martin D. Chapman,Carsten Schou,R. C. Aalberse +10 more
TL;DR: In this paper, the authors measured the airborne and floor dust allergen levels of the cat (Fel d I), dog (Can f I), and mite (Der I and Der II) allergens in 13 houses.
Journal ArticleDOI
Asthma in the Inner City and the Indoor Environment
Elizabeth C. Matsui,Nadia N. Hansel,Meredith C. McCormack,Robert Rusher,Patrick N. Breysse,Gregory B. Diette +5 more
TL;DR: A review of the growing body of evidence that certain indoor environmental exposures contribute to the burden of asthma in the inner city finds certain indoor exposures are more common and occur in higher concentrations in inner-city communities than in suburban communities.
References
More filters
Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Mite faeces are a major source of house dust allergens
TL;DR: Measurements from a radioimmunoassay show that more than 95% of the allergen accumulating in mite cultures is associated with faecal particles.
Journal ArticleDOI
The house-dust mite (Dermatophagoides pteronyssinus) and the allergens it produces. Identity with the house-dust allergen
TL;DR: The finding of the house-dust mite seems to supply an answer to all factors, and the keystone of the theory is formed by the fact that after being made equivalent, extracts of house dust and mite cultures gave skin reactions which were both qualitatively and quantitatively indistinguishable.
Journal ArticleDOI
Mites and house-dust allergy in bronchial asthma
TL;DR: The mites in a large number of dust samples from houses of patients with bronchial asthma were identified and counted: the most common species was Dermatophagoides pteronyssinus, and it was particularly abundant in mattress dust.
Journal ArticleDOI
Effects of anti-mite measures on children with mite-sensitive asthma: a controlled trial.
TL;DR: Mite counts and tests for mite antigen were performed on samples of dust taken from the bedding of 53 children with mite-sensitive asthma and no significant differences emerged in the progress of the two groups, both tending to improve.
Related Papers (5)
Mite faeces are a major source of house dust allergens
Dust mite allergens and asthma—A worldwide problem
Thomas A.E. Platts-Mills,Alain L. de Weck,R. C. Aalberse,Jean Claude Bessot,B. Bjorksten,Edelbert Bischoff,Jean Bousquet,J. E.M.H. Van Bronswijk,G. P. ChannaBasavanna,Martin C. Chapman,Matthew J. Colloff,Robert A. Goldstein,B. Guérin,Barbara Hart,Chein Soo Hong,Koji Ito,W. Jorde,Jens Korsgaard,J. Le Mao,Terumasa Miyamoto,P. Lind,Henning Løwenstein,E. B. Mitchell,Andrew B. Murray,D. Nolte,Philip S. Norman,Gabrielle Pauli,H. R. Ranganath,Charles E. Reed,Jan Reiser,Geoffrey A. Stewart,Keven J. Turner,Daniel Vervloet,Tinghuan Wen +33 more