The distribution of dust mite allergen in the houses of patients with asthma.
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The results suggested that natural exposure to this dust allergen allows occasional fecal particles to enter the lungs and that these particles contain very concentrated allerGEN.Abstract:
Using an inhibition radioimmunoassay for the major allergen from Dermatophagoides pteronyssinus (antigen P1), we studied the distribution of this dust allergen in the houses of patients with asthma. Both bed and floor dust samples contained a wide range of antigen P1, 100 to 100,000 ng/g of fine dust, and this concentration correlated well with the number of mite bodies (r = 0.81, p less than 0.001). We were unable to detect antigen P1 in the air of undisturbed rooms. However, during domestic activity, between 1 and 30 ng were collected on a filter than sampled air for 45 min at 17 L/min. Using a cascade impactor it was shown that greater than 80% of the airborne antigen P1 was associated with particles greater than 10 mu in diameter. Some of the particles containing allergen could be identified because they formed precipitin rings when impacted onto agarose containing rabbit antimite antiserum. These particles had the physical appearance of mite feces, which are the major source of antigen P1 in mite cultures. The results suggested that natural exposure to this dust allergen allows occasional fecal particles to enter the lungs and that these particles contain very concentrated allergen.read more
Citations
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Cluster analysis of molecular components in 100 patients suffering from atopic dermatitis according to the ISAC Multiplex testing
Jarmila Čelakovská,Josef Bukac,R. Vaňková,Eva Cermakova,Irena Krčmová,Jan Krejsek,Ctirad Andrýs +6 more
TL;DR: The cluster analysis for the evaluation of the results in Multiplex ISAC test in atopic dermatitis patients found 10 clusters with different numbers of molecular components that correspond to the association of molecular component into protein families according to their biochemical structure.
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A reintroduction of environmental mite allergen control strategies for asthma treatment and the debate on their effectiveness
TL;DR: It is hypothesized that the absence of evidence for the effectiveness of mite allergen control for asthma treatment applies to the strategy of concurrent bedroom interventions, and the evidence‐based effectiveness of the exposure‐based control strategy appears to be undetermined.
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Dust‐mite‐allergen concentrations in asthmatics' bedrooms in the Quad Cities (Illinois, USA) after the Mississippi River floods of 1993
Luke Curtis,M. Ross,Peter A. Scheff,Victoria Persky,R. Wadden,Viswanathan Ramakrishnan,Daniel O. Hryhorczuk +6 more
TL;DR: D. farinae and D. pteronyssinus allergen levels were significantly higher in homes located in the valley, in homes during April and July‐September, in houses with furred or feathered pets, and in homes with no dehumidifier.
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Survival of the House Dust Mite, Dermatophagoides farinae, at High Temperatures (40–80°C)
John C.S. Chang,Larry G. Arlian,Jacqueline S. Dippold,Christine M. Rapp,DiAnn L. Vyszenski-Moher +4 more
TL;DR: The results of this study indicated that the technique of raising temperatures to above 40°C for a short duration can be used to reduce living house dust mite populations in homes significantly.
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Sources of pollution of indoor air by mite-allergen-containing house dust
TL;DR: In the present study, mite excreta in dust are assessed using an azo dye formation with the mite-metabolism product guanine to evaluate the reliability of the ACAREX test.
References
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Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
Journal ArticleDOI
Mite faeces are a major source of house dust allergens
TL;DR: Measurements from a radioimmunoassay show that more than 95% of the allergen accumulating in mite cultures is associated with faecal particles.
Journal ArticleDOI
The house-dust mite (Dermatophagoides pteronyssinus) and the allergens it produces. Identity with the house-dust allergen
TL;DR: The finding of the house-dust mite seems to supply an answer to all factors, and the keystone of the theory is formed by the fact that after being made equivalent, extracts of house dust and mite cultures gave skin reactions which were both qualitatively and quantitatively indistinguishable.
Journal ArticleDOI
Mites and house-dust allergy in bronchial asthma
TL;DR: The mites in a large number of dust samples from houses of patients with bronchial asthma were identified and counted: the most common species was Dermatophagoides pteronyssinus, and it was particularly abundant in mattress dust.
Journal ArticleDOI
Effects of anti-mite measures on children with mite-sensitive asthma: a controlled trial.
TL;DR: Mite counts and tests for mite antigen were performed on samples of dust taken from the bedding of 53 children with mite-sensitive asthma and no significant differences emerged in the progress of the two groups, both tending to improve.
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