The distribution of dust mite allergen in the houses of patients with asthma.
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The results suggested that natural exposure to this dust allergen allows occasional fecal particles to enter the lungs and that these particles contain very concentrated allerGEN.Abstract:
Using an inhibition radioimmunoassay for the major allergen from Dermatophagoides pteronyssinus (antigen P1), we studied the distribution of this dust allergen in the houses of patients with asthma. Both bed and floor dust samples contained a wide range of antigen P1, 100 to 100,000 ng/g of fine dust, and this concentration correlated well with the number of mite bodies (r = 0.81, p less than 0.001). We were unable to detect antigen P1 in the air of undisturbed rooms. However, during domestic activity, between 1 and 30 ng were collected on a filter than sampled air for 45 min at 17 L/min. Using a cascade impactor it was shown that greater than 80% of the airborne antigen P1 was associated with particles greater than 10 mu in diameter. Some of the particles containing allergen could be identified because they formed precipitin rings when impacted onto agarose containing rabbit antimite antiserum. These particles had the physical appearance of mite feces, which are the major source of antigen P1 in mite cultures. The results suggested that natural exposure to this dust allergen allows occasional fecal particles to enter the lungs and that these particles contain very concentrated allergen.read more
Citations
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Natural Evolution of IgE Responses to Mite Allergens and Relationship to Progression of Allergic Disease: a Review
TL;DR: Individual sensitization profiles towards HDM allergens provide important information to evaluate a patient’s current stage and risk for clinical symptoms and paves the way for an early and adequate prevention and/or treatment of HDM allergy.
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Domestic ventilation rates, indoor humidity and dust mite allergens : are our homes causing the asthma pandemic?
TL;DR: The study can form the basis for assessing minimum winter ventilation rates that can suppress RH below the critical ambient equilibrium humidity of 60% and thus inhibit dust mite colonization and activity in temperate and maritime in‘ uenced climatic regions.
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Mite allergen content in mattress dust of Dermatophagoides‐allergic asthmatics/rhinitics and matched controls
TL;DR: The findings show that in a Rhine valley city such as Strasbourg with a high mite allergen load there is no difference in mite exposure between D. pteronyssinus‐sensitized patients and controls who can be considered not to differ from the general population with respect to atopy.
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Clinical evaluation of patients with complaints related to formaldehyde exposure.
TL;DR: Physicians have or will encounter patients who wish evaluations of a present or potential health effect from formaldehyde, and this article is for the purpose of providing assistance in such evaluation.
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Mite allergen (Der p 1) is not only carried on mite feces
TL;DR: The sources of Der p 1 aeroallergen are investigated by using a new technique, which enables individual particles containing allergen to be visualized, and it is proposed that a low proportion of these large fecal particles would enter the lower airways, and the effects of high localAllergen concentrations from each particle, on chronic exposure, might provide sufficient stimulus to maintain or produce hyperreactivity.
References
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Journal Article
Deposition and retention models for internal dosimetry of the human respiratory tract. Task group on lung dynamics.
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Mite faeces are a major source of house dust allergens
TL;DR: Measurements from a radioimmunoassay show that more than 95% of the allergen accumulating in mite cultures is associated with faecal particles.
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The house-dust mite (Dermatophagoides pteronyssinus) and the allergens it produces. Identity with the house-dust allergen
TL;DR: The finding of the house-dust mite seems to supply an answer to all factors, and the keystone of the theory is formed by the fact that after being made equivalent, extracts of house dust and mite cultures gave skin reactions which were both qualitatively and quantitatively indistinguishable.
Journal ArticleDOI
Mites and house-dust allergy in bronchial asthma
TL;DR: The mites in a large number of dust samples from houses of patients with bronchial asthma were identified and counted: the most common species was Dermatophagoides pteronyssinus, and it was particularly abundant in mattress dust.
Journal ArticleDOI
Effects of anti-mite measures on children with mite-sensitive asthma: a controlled trial.
TL;DR: Mite counts and tests for mite antigen were performed on samples of dust taken from the bedding of 53 children with mite-sensitive asthma and no significant differences emerged in the progress of the two groups, both tending to improve.
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