Journal ArticleDOI
The effect of HLA class I (A and B) and class II (DR) compatibility on liver transplantation outcomes: An analysis of the OPTN database
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TLDR
A careful examination of the OPTN database, with respect to HLA match or mismatch and liver graft survival, reaffirms that HLA matching has no clinically significant impact on this outcome.About:
This article is published in Liver Transplantation.The article was published on 2006-04-01. It has received 75 citations till now. The article focuses on the topics: Transplantation & Liver transplantation.read more
Citations
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Journal ArticleDOI
Human Leukocyte Antigen Matching Estimations in a Hypothetical Bank of Human Embryonic Stem Cell Lines in the Japanese Population for Use in Cell Transplantation Therapy
TL;DR: The relatively low ethnic diversity of the Japanese population may have resulted in a high success rate in beneficial matching, and parthenogenetic hES cell lines can greatly reduce the number required for a higher degree of HLA matching.
Journal ArticleDOI
The liver: a special case in transplantation tolerance.
Volker Benseler,Geoffrey W. McCaughan,Hans J. Schlitt,G. Alex Bishop,David G. Bowen,Patrick Bertolino +5 more
TL;DR: A unified model in which several mechanisms act in concert to induce and maintain tolerance in both naïve and effector T cell compartments is proposed, which will facilitate the development of strategies that specifically inhibit alloreactive memory T cells.
Journal ArticleDOI
Incidence and Severity of Acute Cellular Rejection in Recipients Undergoing Adult Living Donor or Deceased Donor Liver Transplantation
Abraham Shaked,Rafik M. Ghobrial,Rafik M. Ghobrial,Robert M. Merion,T. H. Shearon,Jean C. Emond,Jeffrey H. Fair,Jeffrey H. Fair,Robert A. Fisher,Laura Kulik,Timothy L. Pruett,Norah A. Terrault +11 more
TL;DR: The data do not show an immunological advantage for LDLT, and therefore do not support the application of unique posttransplant immunosuppression protocols for HDLT recipients, and do notsupport theapplication of uniquePosttransplant Immunosuppressive protocols for DDLT recipients.
Journal ArticleDOI
Evidence for human leukocyte antigen heterozygote advantage against hepatitis C virus infection.
TL;DR: Findings constitute evidence for an advantage among carriers of different supertype HLA‐DRB1 alleles against HCV infection progression to end‐stage liver disease in a large‐scale, long‐term study population.
Journal ArticleDOI
Immunosuppression for liver transplantation
TL;DR: The prospect that recipients could potentially be made immunologically tolerant to liver transplants is discussed, and new strategies to preserve transplanted liver allografts for the longest possible time are of paramount importance.
References
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Book
Applied Survival Analysis: Regression Modeling of Time-to-Event Data
TL;DR: Applied Survival Analysis, Second Edition is an ideal book for graduate-level courses in biostatistics, statistics, and epidemiologic methods and serves as a valuable reference for practitioners and researchers in any health-related field or for professionals in insurance and government.
Journal ArticleDOI
Epidemiologic Research: Principles and Quantitative Methods.
TL;DR: In this article, the authors present an overview of the main issues in epidemiology research and propose a method for controlling extraneous factors in the context of epidemiological studies, using Logistic Regression with Interaction, Effect Modification, and synergy.
Book
Epidemiologic Research: Principles and Quantitative Methods
TL;DR: In this article, the authors present an overview of the main issues in epidemiology research and propose a method for controlling extraneous factors in the context of epidemiological studies, using Logistic Regression with Interaction, Effect Modification, and synergy.