Journal ArticleDOI
The effects of electric current applied to skin: A review for transdermal drug delivery
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TLDR
To aid in the development of electrical protocols which safely increase transport across skin, this review discusses the effects of electrical current on: skin electrical properties; sensation, pain, and muscle stimulation; and safety considerations.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 1996-02-08. It has received 255 citations till now. The article focuses on the topics: Transdermal.read more
Citations
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Journal ArticleDOI
Transdermal drug delivery
Mark R. Prausnitz,Robert Langer +1 more
TL;DR: Third-generation delivery systems target their effects to skin's barrier layer of stratum corneum using microneedles, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound for delivery of macromolecules and vaccines.
Journal ArticleDOI
Current status and future potential of transdermal drug delivery
TL;DR: The already significant impact this field has made on the administration of various pharmaceuticals is discussed; limitations of the current technology are explored; methods under exploration for overcoming these limitations and the challenges ahead are discussed.
Journal ArticleDOI
Gyri-precise head model of transcranial direct current stimulation: Improved spatial focality using a ring electrode versus conventional rectangular pad
TL;DR: It is shown that electric fields may be clustered at distinct gyri/sulci sites because of details in tissue architecture/conductivity, notably cerebrospinal fluid (CSF).
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Wearable sweat sensors
TL;DR: The development of wearable sweat sensors is examined, considering the challenges and opportunities for such technology in the context of personalized healthcare and the requirements of the underlying components.
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Skin electroporation for transdermal and topical delivery
TL;DR: Molecular transport through transiently permeabilized skin by electroporation results mainly from enhanced diffusion and electrophoresis, and the efficacy of transport depends on the electrical parameters and the physicochemical properties of drugs.
References
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Book
CRC Handbook of Chemistry and Physics
TL;DR: CRC handbook of chemistry and physics, CRC Handbook of Chemistry and Physics, CRC handbook as discussed by the authors, CRC Handbook for Chemistry and Physiology, CRC Handbook for Physics,
Journal Article
Studies of Thermal Injury: II. The Relative Importance of Time and Surface Temperature in the Causation of Cutaneous Burns*
A R Moritz,F C Henriques +1 more
TL;DR: Although Leach, Peters, and Rossiter made a careful study of the pathological characteristics of different kinds of burns of guinea-pig skin, the extent to which these chges are representative of those that occur in cutaneous burning in man was not disclosed.
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Electroporation of cell membranes.
TL;DR: Electroporation has found applications in introduction of plasmids or foreign DNA into living cells for gene transfections, fusion of cells to prepare heterokaryons, hybridoma, hybrid embryos, and constructing animal model by fusing human cells with animal tissues.
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Direct measurement of skin conductance: a proposal for standardization.
TL;DR: A provisional standard method of measuring tonic skin conductance and GSR (SCR) is advocated, using a constant-voltage method for which circuits are provided useable with Beckman, Grass, and other common polygraphs.