Open AccessJournal Article
The effects of gamma-hydroxybutyrate on sleep.
M. Mamelak,J.M. Escriu,O. Stokan +2 more
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TLDR
It is suggested that GHB may serve as the prototype for a new class of hypnotic compounds derived from natural sources and capable of activating the neurological mechanisms of normal human sleep.About:
This article is published in Biological Psychiatry.The article was published on 1977-04-01 and is currently open access. It has received 105 citations till now. The article focuses on the topics: Non-rapid eye movement sleep & Sleep Stages.read more
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The gamma-hydroxybutyrate signalling system in brain: organization and functional implications.
TL;DR: It is presumed that, under pathological conditions (hepatic failure, alcoholic intoxication, succinic semialdehyde dehydrogenase defects), the rate of GHB synthesis or degradation in the peripheral organ is modified and induces increased GHB levels which could interfere with the normal brain mechanisms.
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GHB: a new and novel drug of abuse.
TL;DR: Drug abuse experts need to familiarize themselves with GHB as possibly representing a new type of drug abuse problem with some unique properties, as it has unique aspects of its pharmacology as well.
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What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications.
Benjamin Boutrel,George F. Koob +1 more
TL;DR: Understanding the exact role of the hypocretin/orexin and dopamine systems in the physiology and pharmacology of sleep-wake regulation may reveal new insights into current and future wakefulness-promoting drugs.
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Simultaneous stimulation of slow-wave sleep and growth hormone secretion by gamma-hydroxybutyrate in normal young Men.
E. Van Cauter,Laurence Plat,Martin B. Scharf,Rachel Leproult,S. Cespedes,Mireille L’Hermite-Balériaux,Georges Copinschi +6 more
TL;DR: The data suggest that pharmacological agents that reliably stimulate SW sleep, such as GHB, may represent a novel class of powerful GH secretagogues.
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Gammahydroxybutyrate: an endogenous regulator of energy metabolism.
TL;DR: Observations suggest that GHB may function naturally in the induction and maintenance of physiological states, like sleep and hibernation, in which energy utilization is depressed, and may also function naturally as an endogenous protective agent when tissue energy supplies are limited.