Journal ArticleDOI
The effects of the bioflavonoid quercetin on squamous cell carcinoma of head and neck origin
Manuel H. Castillo,Eddie Perkins,John H. Campbell,Ralph J. Doerr,James M. Hassett,Chithan Kandaswami,Elliott Middleton +6 more
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TLDR
Quercetin appears to possess a cytotoxic effect on squamous cell carcinoma of head and neck origin both in vivo and in vitro, and the inhibitory effect on malignant cells appears to be selective and dose-dependent.Abstract:
Quercetin exhibits antitumor activity. We investigated the effect of quercetin on the in vitro and in vivo growth of two squamous cell carcinoma cell lines and a normal human lung fibroblast-like cell line. The in vivo effect was evaluated using implantable cell growth chambers implanted subcutaneously in immunocompetent rats. Quercetin was injected intraperitoneally, and multiple dosages were tested. Cells were counted on days 1, 3, 5, and 7, and growth curves were constructed. Quercetin caused inhibition of growth in both squamous cell carcinoma lines. Effect on the fibroblast-like human lung cells was noted only at the maximum concentration. Significant growth inhibition of squamous cell carcinoma was observed in implantable cell growth chambers retrieved 3 days after quercetin treatment. Quercetin appears to possess a cytotoxic effect on squamous cell carcinoma of head and neck origin both in vivo and in vitro. The inhibitory effect on malignant cells appears to be selective and dose-dependent.read more
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The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer
TL;DR: Western medicine has not yet used flavonoids therapeutically, even though their safety record is exceptional, and suggestions are made where such possibilities may be worth pursuing.
Journal ArticleDOI
Wine as a biological fluid: History, production, and role in disease prevention
TL;DR: Red wine provides a more favourable milieu than fruits and vegetables, their other dietary source in humans, and its antioxidant effects have been demonstrated in many experimental systems spanning the range from in vitro studies to investigations in healthy human subjects.
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The Antitumor Activities of Flavonoids
Chithan Kanadaswami,Lung Ta Lee,Ping Ping H. Lee,Jiuan Jiuan Hwang,Ferng Chun Ke,Ying Tung Huang,Ming Ting Lee +6 more
TL;DR: Experimental animal studies indicate that certain dietary flavonoids possess antitumor activity, and the hydroxylation pattern of the B ring of the flavones and flavonols seems to critically influence their activities, especially the inhibition of protein kinase activity and antiproliferation.
The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer
TL;DR: Over 4000 chemically unique unique flavonoids have been identified in plant sources, including phenyl- benzopyrones (phenylchromones) with an assortment of basic structures.
Journal ArticleDOI
Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices
TL;DR: Evidence of anticancer properties of orange juice and indicate that citrus flavonoids are effective inhibitors of human breast cancer cell proliferation in vitro are provided, especially when paired with quercetin, which is widely distributed in other foods.
References
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Journal ArticleDOI
Flavonoids, a class of natural products of high pharmacological potency
TL;DR: The few existing reports on the careful pharmacodynamic, pharmacokinetic and clinical studies which have been made have been summarized to provide a basis for a full-scale investigation of the therapeutic potential of flavonoids.
Book ChapterDOI
The flavonoids. A class of semi-essential food components: their role in human nutrition.
TL;DR: A review of the chemistry, the fate of food flavonoids, and their nutritional effects can be found in this paper, where the authors discuss the antibiotic and/or bacteriostatic effects of foods rich in these compounds.
Journal ArticleDOI
Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange.
Paul Perry,H. J. Evans +1 more
TL;DR: A staining technique that detects sister chromatid exchanges (SCEs) has been used to examine the response of chromosomes in cultured Chinese hamster cells to a wide variety of mutagens–carcinogens.
Journal ArticleDOI
A review of the genetic effects of naturally occurring flavonoids, anthraquinones and related compounds.
TL;DR: Two classes of common phenolic plant pigments contain many members mutagenic in the Salmonella/mammalian microsome assay, and the genetic toxicity of these agents and their dietary intake and metabolic fate in man is assessed.
Journal ArticleDOI
Antiviral effect of flavonoids on human viruses.
TL;DR: The effect of several naturally occurring dietary flavonoids including quercetin, naringin, hesperetin, and catechin on the infectivity and replication of herpes simplex virus type 1 (HSV-1), polio-virus type 1, parainfluenza virus type 3 (Pf-3), and respiratory syncytial virus (RSV) was studied in vitro in cell culture monolayers employing the technique of viral plaque reduction as discussed by the authors.