The effects of wine and tobacco consumption on cognitive performance in the elderly: a longitudinal study of relative risk.
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TLDR
There is no evidence to suggest that wine and tobacco consumption may protect against Alzheimer's disease.Abstract:
Background Evidence relating to the potentially protective effect of smoking and alcohol consumption in relation to senescent cognitive decline and Alzheimer’s disease is inconclusive. Methods The relationship between wine and tobacco consumption and cognitive change was assessed within a longitudinal study of normal elderly people showing recent instability in cognitive functioning using an extensive battery of cognitive tests. Results While moderate wine consumption was found to be associated with a fourfold diminishing of the risk of Alzheimer’s disease (OR = 0.26), as found in other studies, this effect was found to disappear when institutionalization was taken into account. Wine consumption was associated with an increased risk of decline over time in attention and in secondary memory. No protective effect for Alzheimer’s disease was found for smoking, although smoking was associated with a decreased risk for decline over time in attentional and visuospatial functioning. No clear combined effect of smoking and drinking was found, even though smoking was found to increase the risk of decline in language performance when adjusted on wine consumption. Conclusions There is no evidence to suggest that wine and tobacco consumption may protect against Alzheimer’s disease.read more
Citations
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References
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Journal Article
Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area.
Jean-Marc Orgogozo,J. F. Dartigues,Sylviane Lafont,Luc Letenneur,Daniel Commenges,Roger Salamon,S Renaud,M B Breteler +7 more
TL;DR: There is no medical rationale to advise people over 65 to quit drinking wine moderately, as this habit carries no specific risk and may even be of some benefit for their health, and all elderly people to drink wine regularly for prevention of dementia would be however premature at this stage.
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A case-control study of Alzheimer's disease in Australia.
Gerald A. Broe,A. S. Henderson,Helen Creasey,Elizabeth McCusker,Ailsa E Korten,Anthony F. Jorm,W Longley,James C. Anthony +7 more
TL;DR: Significant odds ratios were found for 4 variables: a history of either dementia, probable AD, or Down's syndrome in a 1st-degree relative, and underactivity as a behavioral trait in both the recent and more distant past.
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Risk factors for clinically diagnosed Alzheimer's disease A case‐control study of an Italian population
L. Amaducci,L Fratiglioni,W. A. Rocca,C Fieschi,Paolo Livrea,D Pedone,Laura Bracco,Andrea Lippi,Carlo Gandolfo,G Bino +9 more
TL;DR: Dementia among first- or second-degree relatives and advanced age of the mother at subject's birth (age over 40) were associated with AD, but the previously reported association with antecedent thyroid disease or family history of Down's syndrome was not confirmed.
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Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity
Takeshi Kihara,Shun Shimohama,Hideyuki Sawada,Jun Kimura,Toshiaki Kume,Hanae Kochiyama,Takehiko Maeda,Akinori Akaike +7 more
TL;DR: It is suggested that nicotinic receptor stimulation, especially α‐receptor activation, may be able to protect neurons from degeneration induced by Aβ and may have effects that counter the progress of AD.